Hydrogels crosslinking

Table 2. Swelling of polyacrylamide hydrogels crosslinked with allyl ether of carboxymethyl cellulose (AE CMC)1 [41]...

Hydrogel Crosslinking mode Dissociation signal References... 

To avoid all these drawbacks new wound dressing materials have been tested. So, PEO/PVA hydrogel, crosslinked by electron beams, has been synthesized and tested as dressing on animals wounds. Wounds dressed with a hydrogel healed almost completely within 14 days, while those using gauze were only half-healed within that time. Clinical tests confirmed the safety and effects of this product [234],... 

GENETICALLY ENGINEERED PROTEIN DOMAINS AS HYDROGEL CROSSLINKS... 

Genetically Engineered Protein Domains as Hydrogel Crosslinks... 

An example of this analysis is a modified quartz crystal with a (poly(allyI-amine)-ferrocene hydrogel crosslinked with Glucose Oxidase and immersed in liquid electrolyte which has been studied by electroacoustic... 

TABLE 1. Summary of N,N -(dimethacryloyloxy)alkylamide derivatives effective as hydrogel crosslinking agents. 

TABLE 3. Degradation times for copolymer hydrogels crosslinked with NJ -dimethacryloyloxy)glutarylamide hydrolyzed in a hnffer solntion at pH 7.4 at 37° C. 

Goupil [ 1 ] prepared biomedical articles consisting of biodegradable poly( vinyl alcohol) hydrogels crosslinked with A -methacrylamidoacetaldehyde dimethyl acetal, (I), A -acrylamido-acetaldehyde dimethyl acetal, (11), and l-(2,2-di-methoxyethyl)-3,4-dimethylpyrrole-2,5-dione, (111). 

Davis, T.P. Huglin, M.B. Yip, D.C.F. Properties of poly(V-vinyl-2-pyrrolidone) hydrogels crosslinked with ethyleneglycol dimethacrylate. Polymer 1988, 29, 701-706. 

Water-soluble polymers can be crosslinked electrostatically or covalently to give hydrogels. Crosslinked hydrogels absorb water but do not dissolve. The differences in release of drugs from water-insoluble matrices and from swelling hydrogels should be appreciated. 

Table 28. Values of maximum swelling coefficient Qraax, time to reach this state tm3I, and kinetic parameters1 for two MC hydrogels crosslinked by various agents2... 

Wang W. A novel hydrogel crosslinked hyaluronan with glycol chitosan. J Mater Sci Mater Med 2006 17 1259-1265. 

Demitri, C. Del Sole, R. Scalera, R Sannino, A. Vasapollo, G. Maffezzoli, A. Ambrosio, L. Nicolais, L. Novel superabsorbent cellulose-based hydrogels crosslinked with citric acid. J. Appl. Polym. Sci. 

Skardal A, Zhang J and Prestwich G D (2010d), Bioprinting vessel-like constructs using hyaluronan hydrogels crosslinked with tetrahedral polyethylene glycol... 

Kasper et al. prepared injectable oligo(poly(ethylene glycol)) fumarate (OFF) hydrogels crosslinked by N,N-methylenebisacrylamide for the in vitro release of DNA. It was found that DNA was released in a sustained, linear fashion over the course of 45-62 days and the release kineties was dependent on the molecular weight of the PEG in the OPF. 

Yan, S. R, Yin, J. B., Yu, Y., Luo, K., Chen, X. S., Thermo- and pH-sensitive poly(vinylmethyl ether)/carboxymethylchitosan hydrogels crosslinked using electron beam irradiation or using glutaraldehyde as a crosslinker. Polymer International 2009, 58,1246-1251. 

Nagasawa, N., W acedil sikiewicz, J. M., Seko, N. et al. 2006. Metal adsorption of chitin/chitosan derivatives hydrogels crosslinked with irradiation. JAEA-Review 042 52-55. 

FIGURE 10.9 Schematic iUustration of the ECM-mimicking hydrogels composed of PEG-based hydrogel crosslinked by the oligopeptides which are cleavable by the MMPs. Reproduced from Ref. [44] with permission. Copyright 2003 Wiley-VCH. 

Suwa, K. Wada, Y. Kishida, A. Akashi, M. Synthesis and functionalities of poly(A-vinylalkylaniide). 6. A novel thennosensitive hydrogel crosslinked poly(N-vinylisobutyramide). J. Polym. Sci., Part A Polym. Chem. 1997,35,3377—3384. 

Buyanov, A.L., L.G. Revel skaya and GA. Petravlov skii, Formation and swelling behavior of polyacrylate superabsorbent hydrogels crosslinked by allyl ediers of poly-saccharides, Proc. ACS Div. Polym, Mat. Sci. Eng, 66 (1992) 87-88. 

Chitin was used in combination with poly(acrylic acid) to obtain hydrogels for wound-healing application. For hydrogel crosslinking, an esterification reaction in acid medium between chitin hydroxyl groups and carboxyl moieties of acrylic... 

Fig. 9 a Preparation of PEG hydrogels crosslinked by the polyrotaxane b preparation of PNIPAAm/MA-introduced PRX hydrogels... 

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