Crosslinkers and Degradable Crosslinked Hydrogels Comprising Them

Dimethyl glutarate (0.6 mol) was added to 400 ml of methanol and treated with an aqueous solution of hydroxylamine (50 wt% in water 1.34 mol). The reaction stirred for 85 hours at ambient temperature, and the product was precipitated by introducing 400 ml of ethanol. The precipitate was isolated, and washed three times with ethanol, and vacuum-dried at 40°C for 48 hours the product was isolated in 66% yield as a white powder. 

In a 100-mlround-bottomflaskthe Step 2product was dissolved in DMF and treated with 2-hydroxyethyl acrylate (2.0 g) followed by glycerol and water (20 g), 1 1. The reactor was placed in an oil bath kept at 55°C and the polymerization was initiated using ammonium persulfate (50 mg) and accelerated with 0.1 ml A,A,A,A-tetramethylethy-lenediamine. The hydrogel formed immediately and was immersed in ethanol overnight, washed with ethanol, vacuum-dried for 20 hours, and the product was isolated. 

A summary of base-labile crosslinking agents is provided in Table 1. Hydrolytic stability of homopolymer and copolymer hydrogels are provided in Tables 2 and 3, respectively. 

TABLE 1. Summary of N,N -(dimethacryloyloxy)alkylamide derivatives effective as hydrogel crosslinking agents. 

TABLE 2. Degradation times for crosslinked homopolymer hydrogels hydrolyzed in a buffer solution at pH 7.4 at 37° C. 

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Title Degradable Crosslinkers and Degradable Crosslinked Hydrogels Comprising Them... 

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