Hydrochloric acid with sodium bicarbonate

While keeping the collected deuterioammonia at dry ice-isopropyl alcohol temperature, lithium wire (10 mg) is added, followed by a solution of 3/3-hydroxy-5a-cholest-7-en-6-one (161 50 mg) in anhydrous tetrahydrofuran (4 ml). The reaction mixture is stirred for 20 min, the cooling bath is then removed and the ammonia is allowed to boil under reflux for 40 min. A saturated solution of ammonium chloride in tetrahydrofuran is added dropwise until the deep blue color disappears and then the ammonia is allowed to evaporate. The residue is extracted with ether and the organic layer washed with dilute hydrochloric acid and sodium bicarbonate solution and then with water. Drying and evaporation of the solvent gives a semicrystalline residue which is dissolved in acetone and oxidized with 8 N chromic acid solution. After the usual workup the residue is dissolved in methanol containing sodium hydroxide (0.2 g) and heated under reflux for 1 hr to remove any deuterium introduced at C-5 or C-7. (For workup, see section II-B). 

Water, 15% hydrochloric acid, 10% sodium bicarbonate and finally water. The solvent was stripped off. The residual oil was mixed with 300 ml of 28% aqueous ammonia for 1 hour. The ammonia and water were vacuum distilled at a temperature of 40°C or less. Then 300 cc of carbon tetrachloride was added and the solution dried with sodium sulfate. The solution was cooled at 0°C and then filtered. The crystals were washed with cold carbon tetrachloride and vacuum dried. The yield was 57 g of dried product having a melting point of 55°C to 56.5°C. 

The organic fractions are combined and washed successively with N,N-dimethyl-1,3-propane-diamine, dilute hydrochloric acid, saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic fraction is dried over anhydrous magnesium sulfate. The solvent is then evaporated off. Upon trituration of the residue with methanol, a solid crystallizes, 5-(p-toluovl)-1 -methvlpvrrole-2-acetonitrile, which is removed by filtration and purified by recrystallization from benzene. 

The CHClj/ethanol extract [7] was successively extracted with 5% acetic acid, 5% hydrochloric acid, 5% sodium bicarbonate,... 

Peptide synthesis. Sheehan and co-workers used this water-soluble reagent for a simplified and rapid synthesis of tetra- and pentapeptides without isolation of intermediates. The reagent (I. I equiv.) is added to a solution of the N-carbobenzoxy-amino acid (I equiv.), the amino acid ester hydrochloride or peptide ester hydrochloride (1 equiv.), and triethylamine (1 equiv.) in methylene chloride. After I hr. at room temperature the solution was washed successively with water (to remove excess reagent and the urea), dilute hydrochloric acid, and sodium bicarbonate solution. The curbobenzoxy group Is removed by hydrogenolysis and the product used directly in the next step. ... 

A theory of the biogenesis of the ochotensine bases from those of the berberine group has been studied and the analogue (43) of dehydrocorydaline has been reduced, A-methylated, and debenzylated to the salt (44), which when treated successively with sodium hydroxide, hydrochloric acid, and sodium bicarbonate, gave an analogue of ochotensimine." ... 

Studies in the tropics have reported organic phosphorus in the supernatant after resin extraction, in the sodium bicarbonate extract, in the sodium hydroxide extract before sonication, in the sodium hydroxide extract after sonication, and in the concentrated hydrochloric acid extract. Sodium bicarbonate recovers easily hydrolysable organic phosphorus (Bowman and Cole, 1978), while sodium hydroxide recovers organic phosphorus associated with humic and fulvic acids. Concentrated hydrochloric acid recovers organic phosphorus from more stable pools, although it may also extract bioavailable organic phosphorus from particulate organic matter (Tiessen and... 

Procedure C [131] Add the y or lactone (ca. 4 il) to butylamine (10 1) and heat at 80 °C for 5 h in a screw-capped vial. Dissolve the reaction mixture in chloroform and wash with hydrochloric acid (5%), sodium bicarbonate solution (5%) and finally water. Dry the organic phase over sodium sulphate and evaporate to dryness. 

Separations based upon differences in the chemical properties of the components. Thus a mixture of toluene and anihne may be separated by extraction with dilute hydrochloric acid the aniline passes into the aqueous layer in the form of the salt, anihne hydrochloride, and may be recovered by neutralisation. Similarly, a mixture of phenol and toluene may be separated by treatment with dilute sodium hydroxide. The above examples are, of comse, simple apphcations of the fact that the various components fah into different solubihty groups (compare Section XI,5). Another example is the separation of a mixture of di-n-butyl ether and chlorobenzene concentrated sulphuric acid dissolves only the w-butyl other and it may be recovered from solution by dilution with water. With some classes of compounds, e.g., unsaturated compounds, concentrated sulphuric acid leads to polymerisation, sulphona-tion, etc., so that the original component cannot be recovered unchanged this solvent, therefore, possesses hmited apphcation. Phenols may be separated from acids (for example, o-cresol from benzoic acid) by a dilute solution of sodium bicarbonate the weakly acidic phenols (and also enols) are not converted into salts by this reagent and may be removed by ether extraction or by other means the acids pass into solution as the sodium salts and may be recovered after acidification. Aldehydes, e.g., benzaldehyde, may be separated from liquid hydrocarbons and other neutral, water-insoluble hquid compounds by shaking with a solution of sodium bisulphite the aldehyde forms a sohd bisulphite compound, which may be filtered off and decomposed with dilute acid or with sodium bicarbonate solution in order to recover the aldehyde. 

Treatment of quinoline with cyanogen bromide, the von Braun reaction (17), in methanol with sodium bicarbonate produces a high yield of l-cyano-2-methoxy-l,2-dihydroquinoline [880-95-5] (5) (18). Compound (5) is quantitatively converted to 3-bromoquinoline [5332-24-1], through the intermediate (6) [66438-70-8]. These conversions are accompHshed by sequential treatment with bromine in methanol, sodium carbonate, or concentrated hydrochloric acid in methanol. Similar conditions provide high yields of 3-bromomethylquinoHnes. 

Chemical Reactivity - Reactivity with Water. Reacts violently with water, liberating hydrogen chloride gas and heat Reactivity with Common Materials None if dry. If wet it attacks metals because of hydrochloric acid formed flammable hydrogen is formed Stability During Transport Stable if kept dry and protected from atmospheric moisture Neutralizing Agents for Acids and Caustics Hydrochloric acid formed by reaction with water can be flushed away with water. Rinse with sodium bicarbonate or lime solution Polymerization Not pertinent Inhibitor of Polymerization Not pertinent. 

To the chlorobenzene solution is then added sodium hydroxide dissolved in water and the chlorobenzene is removed by a steam distillation. After all of the chlorobenzene is removed, the precipitate which forms during the distillation is removed by filtration and discarded. The solution is cooled and acidified with hydrochloric acid, precipitating a tan solid. This is removed by filtration and washed acid-free. It Is then treated with sodium bicarbonate solution to remove any acid present and is then washed with water to remove all traces of bicarbonate. After drying approximately a 75% yield of mexenone is obtained. 

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