Hybrid polymer-lipid

Hybrid lipid-polymer membranes are interesting to study in combination with the insertion of proteins. As an example, PDMS-Z>-PMOXA copolymers of different lengths were mixed with various lipids to study phase separation and insertion of the membrane protein Mlokl. By modulating the composition of polymer-lipid mixtures, the properties of the films changed the protein distribution between the polymer and lipid phases. Thus, the distribution of proteins can be controlled according to the composition of the hybrid polymer-lipid membrane. 

New functions can be obtained by modifications of SLNs. Incorporation of Tween 80 and Poloxamer 188 can stabilize SLNs to achieve long-circulating or crossing blood-brain barrier effects [112], Recently, novel nanoparticles called polymer-lipid hybrid nanoparticles (PLNs) were developed [113]. They can entrap cationic anticancer agents (e.g., doxorubicin) effectively by incorporation of an anionic lipophilic polymer into lipids to treat multidrug-resistant (MDR) cancers. 

Wong, H. L., Bendayan, R., Rauth, A. M., and Wu, X. Y. (2006), Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new polymer-lipid hybrid nanoparticles (PLN) for enhanced treatment of multidrug-resistant breast cancer, J. Controlled... 

Wong, H.L. A.M. Rauth R. Bendayan J.L. Manias M. Ramaswamy Z. Liu S.Z. Erhan X.Y. Wu. A new polymer-lipid hybrid nanoparticle system increases cytotoxicity of doxorubicin against multidrug-resistant human breast cancer cells. Pharm. Res. 2006, 23, 1574—1585. 

BBS, blood-brain barrier LDL, low-density lipoprotein PLN, polymer-lipid hybrid nanoparticles SLN, solid lipid nanoparticles. 

Wong HL, Rauth AM, Bendayan R, Wu XY. Combinational treatment with doxorubicin and GG918 (Elacridar) using polymer-lipid hybrid nanoparticles (PLN) and evaluation of strategies for multidrug-resistance reversal in human breast cancer cells. 

Wong HL, Bendayan R, Rauth AM, Xue HY, Babakhanian K, WuXY. Amechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymer-lipid hybrid nanoparticle (PLN) system. J Pharmacol Exp Ther 2006 317 1372-1381. 

WongHL, Rauth AM, Bendayan R, WuXY. Evaluation of the in vivo efficacy, toxicity and lymphatic drainage of loco-regional administered polymer-lipid hybrid nanoparticles (PEN) loaded with doxorubicin in a murine solid tumor model. Eur J Pharm Biopharm 2007 65 300-308. 

Wong, H., Rauth, A.M., Bendayan, R., Wu, X.Y. In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PEN) formulation of doxorubicin in a murine solid tumor model. Eur. J. Pharm. Biopharm. 

Figure 6.5 (A) Schematic representation of a pol mier-lipid hybrid vesicle, surface functionalized with HER2/neu receptor. (B) Polymer-lipid vesicles from PEO-PBD/HSPC blends show significantiy enhanced tumor targeting activity compared to the block copol mier alone.

Kumbhar, D. and V. Pokharkar. Physicochemical investigations on an engineered lipid-polymer hybrid nanoparticle containing a model hydrophilic active, zidovudine. Colloid Surface A, 436 (2013) 714—725. 

Several methods are used to produce lipid-polymer hybrids. Spray drying and spray freeze drying are two of the most attractive methods since they are cost-effective and readily scalable. In these methods, the drug and the polymer are dissolved in an organic solvent and then spray dried/spray freeze dried to produce matrix particles. The particles are then coated with a lipid film to produce... 

FIGURE 50.4 Lipid-polymer hybrid-based drug delivery system. 

Farokhzad et al. reported the immnnological characterization of lipid-polymer hybrid nanoparticles and proposed a method to control the levels of complement activation induced by these nanoparticles. In this method, the nanoparticle snrface was modified by attaching methoxyl, carboxyl, and amine groups. It was found that the snrface chemistry significantly affects human plasma and serum protein adsorption patterns. ... 

Wn et al. demonstrates that a lipid-polymer hybrid drug delivery systan loaded with doxorubicin is effective for tnmor treatment in a well-established animal model. Tumor growth delay and tnmor necrosis were observed in tnmors treated with the lipid-polymer hybrid formulation of doxorubicin. It was fonnd that these lipid-polymer hybrids carrying anticancer agents were useful for loco-regional treatment of breast cancer with an improved therapeutic index. 

Wang, Y., Kho, K., Cheow, W.S., Hadinoto, K. A comparison between spray drying and spray freeze drying for dry powder inhaler formulation of drug-loaded lipid-polymer hybrid nanoparticles. Int. J. Pharm. 2012, 424 (1-2), 98-106. 

Salvador-Morales, C., Zhang, L., Langer, R., Farokhzad, O. Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups. Biomaterials 2009, 30 (12), 2231-2240. 

There is more work in this area, but most of it revolves around the development of PNIPAM-stabilized lipid/polymer hybrid liposomes for drag delivery and receptor-mediated delivery of these liposomes to cells. " Both of these topics are outside the scope of this review. 

Zhang, L.F., Chan, J.M., Gu, F.X., Rhee, J.W., Wang, A.Z., Radovic-Moreno, A.F., Alexis, F., Langer, R., Farokhzad, O.C. Self-assembled lipid-polymer hybrid nanoparticles A robust drug delivery platform. ACS Nano. 2(8), 1696-1702 (2008). doi 10.1021/Nn800275r... 

Chapters deal with carbon-mineral hybrids and their mosaic surface structures, and interfacial phenomena at the surface of natural and synthetics polymers. They also explore a variety of biosystems that are much more complex, including biomacromolecules (proteins, DNA, and lipids), cells and tissues, and seeds and herbs. The authors cover trends in interfacial phenomena investigations, and the final chapter describes NMR and other methods used in the book. This text presents a comprehensive description of a large array of hard and soft materials, allowing the analysis of the structure-property relationships and generalities on the interfacial behavior of materials and adsorbates. 

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