Thermal Inkjet Spray Freeze-Drying

The use of thermal inkjet spray freeze-drying for fabrication of in-halable, excipient-free salbutamol sulfate was investigated (86). A modified Hewlett-Packard printer was used to atomize aqueous salbutamol sulfate solutions into liquid nitrogen. Then, the frozen droplets were subjected to freeze-drying. 

Thermal inlqet spray freeze-drying could process salbutamol sulfate solutions up to 15%. Porous particles with a diameter of 35 pm were produced (86). 

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Thermal inkjet spray freeze-drying was used to produce inhalable particles of terbutaline sulfate (37). Scanning electron micrograph images proved that the particles are spherical, highly porous and suitable for aerosolization from a capsule-based dry-powder device. There is no need for additional experiments. 

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