Hybrid delivery systems

The DDSs based on cationic polymers include polyelectrolyte complexes (PECs), micro- and nanoparticles, capsules, hybrid delivery systems, injectable hydrogels, liposomes, micelles, penetration enhancers, and release triggers. This distinction is, however, not a clear-cut one and some of the... 

A schematic diagram of a chromatograph for SFC is shown in Figure 6.10. In general, the instrument components are a hybrid of components developed for gas and liquid chromatography that have been subsequently modified for use with supercritical fluids. Thus, the. fluid delivery system is a pump modified for pressure control and the injection system a rotary valve similar to components used in liquid chromatography. The column oven and... 

Schiraldi et al. [64] have developed this kind of material by combining silica particles and pHEMA. pHEMA is a biocompatible hydrogel that has been widely studied in the past decades due to its chemical-physical structure and mechanical properties. It has been widely used in ophthalmic prostheses (contact or intraocular lenses), vascular prostheses, drug delivery systems and soft-tissue replacement [65]. These authors have shown that by incorporating silica nanoparticles, the resulting hybrid material is highly biocompatible and promotes bone cell adhesion and proliferation of bone cells seeded on it.1 ... 

Brownlie, A., Uchegbu, I.F., Schatzlein, A.G. (2004). PEI-based vesicle-polymer hybrid gene delivery system with improved biocompatibility. Int. J. Pharm., 274 (1-2), 41-52. 

Polymer (membrane/matrix) hybrid-type drug delivery systems. 

Polymer (Membrane/Matrix) Hybrid-Type Drug Delivery Systems... 

Fig. 13 The controlled release of drug molecules from a (membrane-matrix) hybrid-type drug delivery system in which solid drug is homogeneously dispersed in a polymer matrix, which is then encapsulated inside a polymeric membrane, where D, P, and h are the diffusivity, permeability, and thickness, respectively, and the subscripts p, m, and d denote the drug depletion zone in the polymer matrix, polymer coating membrane, and diffusion layer, respectively.

Global carbon-recycling energy delivery system for CO mitigation (III) Fossil/solar energy hybridization system for utilization of carbon as solar energy carrier... 

One of the earliest approaches to creating polymer-peptide hybrid materials was based on the introduction of peptide moieties in the polymer side chain [11]. These architectures have been of particular interest for the development of drug delivery systems with a high loading capacity as well as for systems in which case the bioactivity is related to having multiple copies of a peptide in close proximity of each other. 

There is an increasing trend to consider nanoparticles as part of other delivery systems to create what are in effect hybrid systems. Dendrimers and dendrons can thus be found as particles in emulsions or vesicles. Macromolecular-dendrimer complexes (dendriplexes) may be incorporated in polylactic-co-glycolic acid (PLGA) nanoparticles (105). Dendrimers may also be grafted to linear polymers (as shown in Fig. 20). 

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