Vesicles polymer hybrid

Brownlie, A., Uchegbu, I.F., Schatzlein, A.G. (2004). PEI-based vesicle-polymer hybrid gene delivery system with improved biocompatibility. Int. J. Pharm., 274 (1-2), 41-52. 

Historically, after the development of oligopeptide-based vesicles, several groups developed and characterized vesicles using polypeptide hybrid systems consisting of polypeptide and synthetic polymer blocks [17-19]. Soon thereafter, vesicles formed entirely from polypeptides, such as poly(L-lysine)-h-poly(L-leucine) and poly(L-lysine)-h-poly(L-glutamate), were developed [20, 21]. This review will focus on recent developments in the formation of vesicles composed of polypeptide hybrid or polypeptide systems, as well as the potential promise of these systems as effective dmg delivery vehicles. A specific example of a polypeptide-based vesicle is shown in Fig. 1, where the hydrophobic segment is a-helical and the hydrophilic segment is a random coil. 

There is an increasing trend to consider nanoparticles as part of other delivery systems to create what are in effect hybrid systems. Dendrimers and dendrons can thus be found as particles in emulsions or vesicles. Macromolecular-dendrimer complexes (dendriplexes) may be incorporated in polylactic-co-glycolic acid (PLGA) nanoparticles (105). Dendrimers may also be grafted to linear polymers (as shown in Fig. 20). 

H.-J. Choi, C. D. Montemagno, Light-driven hybrid bioreactor based on protein-incorporated polymer vesicles, IEEE Trans. NanotechnoL, 2007, 6, 171-176. 

Gallot et al. published one of the earliest reports on the preparation of PLL-based hybrid block copolymers. The synthetic segments in these copolymers were primary amine-terminated polystyrene or polybutadiene that were used to initiate the ROP of ZLL-NCA. The authors intended to use the hybrid conjugates as a model for biological membranes. In the following years, several reports emerged on the synthesis of PLL hybrid block copolymers based on macroinitiators prepared by vinyl monomer polymer-ization. ° The pH and temperature dependence of the copolymer vesicles formed in solution was investigated. ... 

Figure 6.5 (A) Schematic representation of a pol mier-lipid hybrid vesicle, surface functionalized with HER2/neu receptor. (B) Polymer-lipid vesicles from PEO-PBD/HSPC blends show significantiy enhanced tumor targeting activity compared to the block copol mier alone.

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