Hyaluronic acid-based

Cloyd JM et al (2007) Material properties in unconfined compression of human nucleus pulposus, injectable hyaluronic acid-based hydrogels and tissue engineering scaffolds. Eur Spine J 16(11) 1892-1898... 

Shen Y, Li Q, Tu J et al (2009) Synthesis and characterization of low molecular weight hyaluronic acid-based cationic micelles for efficient siRNA delivery. Carbohydr Polym 77 (1) 95—104... 

L. A. Solchaga, J. E. Dennis, V. M. Goldberg, and A. I. Caplan, Hyaluronic acid-based polymers as cell carriers for tissue-engineered repair of bone and cartilage. J. Orthop. Res. 17, 205-123 (1999). 

Hyalofill Hyaff (hyaluronic acid-based hydrogels) Convatec, S.A. 

Hyaluronic acid is a linear polysaccharide formed from disaccharide units containing N-acetyl-D-glucosamine and glucuronic acid. Since it is present in almost all biological fluids and tissues, hyaluronic acid-based materials are very useful in biomedical applications. After cellulose, chitin is the second most abundant natural polysaccharide resource on earth. Chitin and its de-acetylated derivative chitosan are natural polymers composed of N-acetylglucosamine and glucosamine. Both chitin and chitosan have excellent properties such as biodegradability, biocompatibility, non-toxicity, hemostatic activity and antimicrobial activity. Chitin and its derivatives are widely used in various fields of medicine. 

Tan HP, Chu CR et al (2009) Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering. Biomaterials 30 2499-2506... 

Ballore L, Orru F, Nicolini F, Contini SA, Galletti G, Gherli T. Experimental results of the use of hyaluronic acid-based materials (CV Seprafilm and CV Sepracoat) in postoperative pericardial adhesions. Acta Biomed Ateneo Parmense 2000 71 159-166. 

Kim J, Kim I, Cho T, Lee K, Hwang S, Tae G, Noh I, Lee S, Park Y, Sun K. Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic pro-tein-2 and human mesenchymal stem cells. Biomaterials 2007 28 1830-1837. 

Greenawalt, K., Basi, L., Muir, C. and Burns, J., Physical properties of hyaluronic acid-based bioabsorbable membrane for the prevention of post-surgical adhesion, Mater. Res. Soc. Symp. Proc., 292, 265, 1993. 

Bajaj, G. Kim, M.R. Mohammed, S.I. Yeo, Y. Hyaluronic acid-based hydrogel for regional delivery of paclitaxel to intraperitoneal tumors. J. Control. Release 2012 158 (3), 386-392. 

Kong, M. Chen, X.G. Kweon, D.K. Park, H.J. Investigations on skin permeation of hyaluronic acid based nanoemulsion as transdermal carrier. Carbohydr. Polym. 2011, 86 (2), 837-843. 

K. Hemmrich, D. von Heimburg, R. Rendchen, C. Di Bartolo, E. Milella, N. Pallua, Implantation of preadipocyte-loaded hyaluronic acid-based scaffolds into nude mice to evaluate potential for soft tissue engineering. Biomaterials 26 (34) (2005) 7025-7037. 

A. Borzacchiello, et al.. Structural and rheological characterization of hyaluronic acid-based scaffolds for adipose tissue engineering. Biomaterials 28 (2007) 4399—4408. 

M. Halbleib, T. Skurk, C. de Luca, D. von Heimburg, H. Hauner, Tissue engineering of white adipose tissue using hyaluronic acid-based scaffolds. 1 in vitro differentiation of human adipocyte precursor cells on scaffolds. Biomaterials 24 (2003) 3125-3132. 

Jha A K, Hule R A, Jiao T, Teller S S, Clifton R J, Duncan R L, Pochan D J and Jia X (2009), Structural analysis and mechanical characterization of hyaluronic acid-based doubly cross-linked networks , Macromolecules, 42, 537-546. 

Jia X, Yeo Y, Clifton R J, Jiao T, Kohane D S, Kohler J B, Zeitels S M and Langer R (2006), Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration , Biomacromolecules, 7, 3336-44. 

Jia, X. Q., Burdick, J. A., Kohler, J., Clifton, R. J., Rosowski, J. J., Zeitels, S. M. Langer, R. (2004) Synthesis and characterization of in situ cross-linkable hyaluronic acid-based hydrogels with potential application for vocal fold regeneration. Macromolecules, 37, 3239-3248. 

Park, Y. D., Tirelli, N. Hubbell, J. A. (2003) Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks. Biomaterials, 24, 893-900. 

Fig. 29. Comparative listing of the properties (concentration, molecular weight, and viscosity at a shear rate of 0) of a selection of various commercially available hyaluronic-acid-based products (listed by declining molecular weight values as described by the manufacturer) n.i. = no information provided...

HY = hyaluronic acid based viscoelastic, HPMC = hydroxypropylmethylcellulose, ns = not statistically significant... 

Sannino A, Madaghiele M, Conversano F, Mele G, Maffezzoli A, Netti PA, Ambrosio L, Nicolais L (2004) Cellulose derivative-hyaluronic acid-based microporous hydrogels cross-linked through divinyl sulfone (DVS) to modulate equilibrium sorption capacity and network stability. Biomacromolecules 5 92-96... 

To mimic the physiological barriers of cell migration in the tissue, natural or artificial scaffold matrix are incorporated inside the microfiuidic chip in a specific fashion as defined by the experimental studies. Collagen, Matrigel, alginate, and hyaluronic acid-based scaffolds are some of the examples that have been used for this purpose. The choice of scaffold matrix is largely... 

Wang, X., He, J., Wang, Y., Cui, F.Z., 2012. Hyaluronic acid-based scaffold for central neural tissue engineering. Interface Focus 2, 278-291. 

Xu X, Jha AK, Harrington DA, Farach-Carsonb MC, Jia X. Hyaluronic acid-based hydrogels from a natural polysaccharide to complex networks. Soft Matter. 2012 8 3280-94. 

Collins MN, Birkinshaw C. Hyaluronic acid based scaffolds for tissue engineering—A review. CarbohydrPolym. 2013 92 1262-79. 

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