Hyaluronic acid-based systems

M.G. Cascone, L. Di Silvio, B. Sim, and S. Downes, Collagen and hyaluronic acid based polymeric blends as drug dehvery systems for the release of physiological concentrations of growth hormone, / Mater. Sci. Mater. Med., 5 (9-10), 770-774,1994. 

Petersen, S., Kaule, S., Teske, M., et al. Development and in vitro characterization of hyaluronic acid-based coatings for implant-associated local drug delivery systems. J. Chem. (2013). doi 10.1155/2013/587875... 

Design of Multifunctional Hyaluronic Acid-based Delivery Systems... 

Huntsman solvent-based collection and refining system, 15 506 Huron-Dow process, 14 42, 53 Huygens principle, 17 424 H values, 23 284 Hyaluronan, 20 577 Hyaluronic acid, 4 706 20 456 classification by structure, 4 723t function as ingredient in cosmetics, 7 829t... 

Another early attempt to formulate a nanoparticulate system for the delivery of pilocarpine was made by Gurny [99], This formulation was based on pilocarpine dispersed in a hydrogen CAP pseudolatex formulation. Gurny and co-workers [101] compared the formed nanoparticles to a 0.125% solution of hyaluronic acid some years after their first investigation and found that the viscous hyaluronic acid system showed a significantly longer retention time in front of the eye than the pseudolatex formulation. 

Orr (43) used dimethyl sulfoxide as a free radical sink to inhibit the effect of Cu and ascorbic acid on catalase and 8-glucuronidase as well as the degradation of hyaluronic acid. The formation of a radical from ascorbic acid and Cu in water was detected by EPR (44). Based on an EPR spectroscopic study of ascorbic acid during oxidation of methyl-arachidonate-enriched liposomes, ascorbic acid may be important in preventing free radical damage in the central nervous system (45). 

Creuzet, C., Kadi, S., Rinaudo, M., Auzely-Velty, R. New associative systems based on alkylated hyaluronic acid. Synthesis and aqueous solution properties. Polymer 47, 2706-2713 (2006)... 

Chitosan-based nano- and microparticles are widely used for fabrication of controlled dmg release systems. Numerous studies have demonstrated that chitosan and its derivatives (A-trimethyl chitosan, mono-A-carboxymethyl chitosan, etc.) are effective and safe for absorption enhance to improve mucosal (nasal, peroral) delivery of hydrophylic macromolecules, such as peptide and protein dmgs as well as heparins [37,38]. This absorption enhancing effect of chitosan is caused by the opening of intercellular tight junctions, thereby favoring the paracellular transport of macro-molecular dmgs. Recently, a series of successful model chitosan-based polymer systems for mucosal dmg delivery have been reported. Thus, Lim et al. [39] have proposed novel polymer microparticles based on combination of hyaluronic acid and chitosan hydroglutamate... 

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