Design of Multifunctional Hyaluronic Acid-based Delivery Systems

1 Design of Multifunctional Hyaluronic Acid-based Delivery Systems 

2 Overcoming the Challenges In Encapsulating Small Interfering Ribonucleic Acid and Small Molecule Drugs 

As stated in the previous section, Jiang and co-workers, developed a PEI conjugated HA derivative with 24 mol% PEI content for target-specific intracellular siRNA delivery. They reported that HA modified with less than 25 mol% of PEI was considered not to affect its receptor-mediated endocjniosis [21]. 

Functionalised HA Self- siRNA Silencing Hydrodynamic diameter of the siRNA Charge (mV) + 

Derivative assembly encapsulation activity in cancer cells encapsulated nanoparticles (nm) siRNA 

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