Humulin regular

NPH Isophane Human Insulin Suspension. NPH isophane insulin, also called Humulin N, Insulatard NPH Human, or Novolin N is an intermediate-acting form of human insulin produced by recombinant DNA techniques. Mixtures Humulin 70/30 and Novolin 70/30 contain 70% NPH isophane and 30% regular, whereas Humulin 50/50 contains 50% NPH isophane and 50% regular. It is adrninistered subcutaneously and should not be given intravenously. Absorption is delayed because the insulin is conjugated with protamine in a complex of reduced isoelectric solubiUty. Therapeutically, this preparation is probably comparable to purified porcine NPH insulin. However, human NPH insulin may have a slightly shorter duration of action than comparable purified porcine products. 

Administer regular humulin insulin subcutaneously 30 minutes before meals and at bedtime according to the following blood glucose levels. 

Care must be taken when giving insulin to use the correct insulin. Names and packaging are similar and can easily be confused. The nurse carefully reads all drug labels before preparing any insulin preparation. For example, Humalog (insulin lispro) and Humulin R (regular human insulin) are easily confused because of die similar names. 

Short-acting insulins Humulin R (regular) No 100 units, 10-mL vial 500 units, 20-mL vial... 

Biphasic insulins are fixed dose combinations of a short-acting and intermediate-acting insulin in various proportions. Examples are Humulin, a biosynthetic human insulin (rDNA origin) suspension with respectively 20%, 30% and 40% regular and 80%, 70% and 60% isophane insulin and Mixtard, a biphasic biosynthetic human insulin suspension with respectively 10%, 20% and 40% soluble and 90%, 80% and 60% isophane insulin. 

Rapid Acting Humulin R, Novolin R, Novolog, Humalog, Regular Ilefin II. 

Novolin is available in four formulations Regular (R), NPH (N), Lente (L), and Novolin 70/30. They correspond to the several formulations of Humulin. Novolin 70/30, Novolin N, and Novolin R are supplied in prefilled cartridges and in prefilled disposable syringes. Velosulin BR is a sterile solution of human insulin (rDNA origin) in a phosphate buffer. 

Regular insulin human injection (rDNA origin) [FDA for Humulin R]... 

HUMULIN R REGULAR Eli Lilly U-500 (concentrated insulin human injection,... 

Humulin (R, L, N, U, 50/50, and 70/30). Human insulin manufactured by Eli Lilly and Company has the trademark Humulin and is available in six formulations—Regular (R), NPH (N), Lente (L), Ultralente (U), 50% human insulin isophane suspension (NPH)/50% human insulin injection (buffered regular) (50/50), and 70% human insulin isophane suspension (NPH)/30% human insulin injection (buffered regular) (70/30). 

Regular insulin 0.5-1 2-4 5-7 Humulin R Novolin R Regular lletin II... 

Regular Humulin (Lilly) Human U100, U500... 

All of these agents (except insulin lispro, insulin aspart, insulin glargine, and U500 regular Humulin) are available without a prescription. All insulins should be refrigerated and brought to room temperature just before injection. 

Human insulin from E coli is available for clinical use as Humulin (Lilly) and dispensed as either regular, NPH, lente, or ultralente Humulin. Human insulin prepared biosynthetically in yeast is marketed by Novo Nordisk as human insulin injection in regular, lente, and NPH forms Novolin R, Monotard Human Insulin (Novolin L), and Novolin N. The same company also produces a human insulin marketed as Velosulin (regular) that contains a phosphate buffer. This reduces aggregation of regular insulin molecules when used in infusion pumps. However, because of the tendency of phosphate to precipitate zinc ions, Velosulin should not be mixed with any of the lente insulins. 

Humulin R Novolin R Zinc-insulin crystalline suspension (acid regular) Rapid onset, short duration Start, 0.5 h peak, 2.5-5 h end, 8 h... 

Humulin N Novolin N Isophane suspension protamine, zinc crystalline insulin (buffer water for injection) Intermediate-acting, slower onset, longer duration than regular insulin Start, 1.5 h peak, 4-12 h end, up to 24 h... 

HUMULIN R REGULAR U-500 (concentrated insulin human injection, USP) [/s call expressed biosynthetic human insulin] Eli Lilly 20 mL vials of zinc-insulin crystals dissolved in a clear fluid 500 Units/mL 100 units/ mL (U-100) 0.24 mg sodium citrate 1.04 mg citric acid monohydrate 9.6 mg mannitol 0.8 mg polysorbate 80 16mg/mL glycerin, 2.5mg/mL m-cresol as a preservative 0.085 mg/mL (0.017 mg/ 100 units) zinc-oxide (sodium hydroxide and/or hydrochloric acid may be added during manufacture to adjust the pH)... 

Humulin R, lletin II Regular, Novolin R, Novolin RPenHIl, NovoIIn R Prefilled, Velosulin BR... 

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