Intermediate-Acting: NPH

Intermediate-acting (NPH, Humulin N, Lente, and Humulin L insulin) Onset 1 to 2 hours, peak 6 to 12 hours, duration 18 to 24 hours... 

Intermediate-acting NPH insulin (isophane insulin suspension USP) Human, pork 8-12 18-24... 

The pharmacokinetic profiles for both the NPH crystals and the co-crystals also reflected a similar pattern. Co-crystals containing 75% C8-HI demonstrated a more uniform and favorable pharmacokinetic profile over a period of 24 hours than the NPH crystals. Studies measuring the insulin AUC indicated a much faster absorption rate for the NPH crystals i.e. higher insulin AUC values) in the first 12 hours than the co-crystals, in accordance with the dissolution results. However, in the 12-24 hour period, there was a significant decrease in the AUC for the NPH insulin, while that for the co-crystals remained comparable to the 0-12 hour period. This uniformity and prolonged absorption rate made the co-crystals more suitable for basal therapy in gly-cemic control than the existing intermediate-acting NPH crystals. 

NPH Isophane Human Insulin Suspension. NPH isophane insulin, also called Humulin N, Insulatard NPH Human, or Novolin N is an intermediate-acting form of human insulin produced by recombinant DNA techniques. Mixtures Humulin 70/30 and Novolin 70/30 contain 70% NPH isophane and 30% regular, whereas Humulin 50/50 contains 50% NPH isophane and 50% regular. It is adrninistered subcutaneously and should not be given intravenously. Absorption is delayed because the insulin is conjugated with protamine in a complex of reduced isoelectric solubiUty. Therapeutically, this preparation is probably comparable to purified porcine NPH insulin. However, human NPH insulin may have a slightly shorter duration of action than comparable purified porcine products. 

Intermediate-acting insulins (NPH) Humulin N No InnoLet Vial, prefilled pen... 

Neutral protamine hagedorn (NPH) is intermediate-acting. Variability in absorption, inconsistent preparation by the patient, and inherent pharmacokinetic differences may contribute to a labile glucose response, nocturnal hypoglycemia, and fasting hyperglycemia. 

Intermediate Acting Humulin R, Novolin R, Renfe Ilefin II, Humulin N, Novolin N, NPH Illefin II. 

Intermediate-acting insulin (e.g., NPH or isophane, lente, or zinc insulin)... 

Intermediate acting insulin lente, biosynthetic insulin NPH, biosynthetic... 

Semilente insulin is a suspension of amorphous insulin zinc. The onset is 1-3 hours after subcutaneous administration, reaches maximum effect in 5-10 hours and the effect lasts 10-16 hours. Isophane insulin (NPH Neutral solution. Protamine, Hagedorn s laboratoiy insulin) is an intermediate-acting preparation prepared with protamine. The maximum effect is reached in 4-12 hours and lasts 8-26 hours. Patients using these preparations who present for cardiac surgery are at increased risk for anaphylactic reactions to protamine. Ultralente insulin is a long-acting preparation formed with zinc rather than protamine. Zinc retards the release of insulin and these preparations have a duration of up to 36 hours. Protamine zinc insulin, which contains both protamine and zinc, has a duration of 28-36 hours. 

NPH insulin is an intermediate-acting insulin whose absorption and the onset of action are delayed by combining appropriate amounts of insulin and... 

Insulin suspensions. When it is injected as a suspension of insulin-containing particles, dissolution and release of the hormone in subcutaneous tissue is retarded (extended-action insulins). Suitable particles can be obtained by precipitation of apolar, poorly water-soluble complexes consisting of anionic insulin and cationic partners, e.g., the polycationic protein protamine. In the presence of zinc ions, insulin crystallizes crystal size determines the rate of dissolution. Intermediate-acting insulin preparations (NPH or isophane Lente) act for 18-26 hours, slow-acting preparations (protamine zinc, ultralente) for up to 36 hours. 

Novolin R (regular) Intermediate-acting Insulins (NPH) No Insulin pen, vial, or 3-mL pen cartridge, and InnoLet... 

Glargine has a similar insulin receptor affinity as NPH (Neutral Protamine Hagedom, an intermediate-acting insulin that initially achieves slower action through the addition of protamine to short-acting insulin) so that once absorbed in the circulation, glargine is... 

Intermediate-acting insulins are either the neutral protamine Hagedorn insulin (NPH isophane insulin suspension) or the Lente insulin (insulin zinc suspension) the former is a suspension of the insulin-protamine-zinc complex in a phosphate buffer and the latter is a mixture of crystallized and amorphous insulin in acetate buffer. These preparations have an onset of action within about 2h, peak activity after about 4-12 h, and a duration of up to 24 h (Table 4). Commercially available mixtures of soluble insulins and isophane insulins have activities that would normally place them within the intermediate-acting category. Mixed insulin-zinc suspensions are sometimes classified as either intermediate- or long-acting as the duration of action may be up to 30 h. 

Intermediate-acting insulins NPH Humulin N Lilly No cartridge, and InnoLet Vial, prefilled pen others 28 days Vial 28 days ... 

NPH insulin is neutral protamine hagedorn insulin. It is complexed with protamine and is intermediate-acting. 

Intermediate acting isophane insulin (NPH) Long-acting insulin analogues Cloudy 0.5-1.5 h 4-6h 8-16 h... 

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