Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Humanized monoclonal antibodies Campath

Hale, G., Dyer, M.J.S., Clark, M.R., et al. (1988). Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H. Lancet, 2, 1394-1399. [Pg.141]

Mabcampath (EU) or Campath (USA) alemtuzumab a humanized monoclonal antibody directed against CD52 surface antigen of B-lymphocytes) Millennium ILEX (EU) Berlex, ILEX Oncology Millennium Pharmaceuticals (USA) Chronic lymphocytic leukaemia... [Pg.381]

Osterborg, A., Fassas, A. S., Anagnostopoulos, A., Dyer, M. J., Catovsky, D., and Mellstedt, H. (1996). Humanized CD52 monoclonal antibody Campath-IH as first-line treatment in chronic lymphocytic leukaemia. Br. J. Haematol. 93, 151-153. [Pg.415]

Alemtuzumab (campath-lH) is a humanized monoclonal antibody specific for the CDw52 antigen, present on cell membranes of lymphocytes and monocytes. It has been used for treatment of patients with rheumatoid arthritis and vasculitis, is being investigated for the treatment of chronic lymphocytic leukemia, and has been used to deplete circulating lymphocytes in patients with multiple sclerosis (1). In 2001, alemtuzumab was approved in Europe for the treatment of chronic B cell lymphocytic leukemia that had been treated previously with alkylating agents and was refractory to fludarabine (2). It has also been used for induction of immunosuppression/tolerance in liver transplant recipients (3,4) and kidney/pancreas transplant recipients (5). [Pg.71]

Synonyms Campath-IH DNA-derived Humanized Monoclonal Antibody Humanized IgG I Anti-CD52 Monoclonal Antibody Trade names Campath (Berlex) MabCampath (Schering) Indications B-cell chronic lymphcyotic leukemia, non-Hodgkin s lymphoma... [Pg.15]

Campath , alemtuzumab, a humanized monoclonal antibody used in the treatment of B-cell chronic lymphocytic leukemia. The campath-IH family of antibodies recognize an abundant glycoprotein on virtually all human lymphocytes. Campath (Millenium Pharm. Inc. and ILEX Oncology Inc.) was registered in the USA in 2001 [M. A. van Dijk, J. G. J. van den Winkel, Curr. Opin. Chem. Biol. 2001, 5, 368]. [Pg.62]

A hydrophobic interaction membrane chromatography method for rapid and efficient separation and analysis of monoclonal antibodies aggregates, able to resolve Campath-IH monomer, dimer, trimer, tetramer, and pentamer, was recently reported [269]. Other applications of hydrophobic interaction membrane chromatography include the separation of model proteins [270], the purification of humanized monoclonal antibody using a stack of microporous synthetic membranes [271], and the fractionation of human plasma proteins using a 0.1 pm microporous PVDF membrane [272]. [Pg.134]

CD52 monoclonal antibody, humanized [SY] CAMPATH-1 [TR former reg. to Welcome Foundation]... [Pg.500]

Rebello, P.R.U.B., Hale, G., Friend, P.J., Cobbold, S.P., and Waldmann, H. (1999) Anti globulin responses to rat and humanized CAMPATH 1 monoclonal antibody used to treat transplant rejection. Transplantation, 68, 1417 1419. [Pg.35]

Anecdotal responses have been cited with cyclosporin A (206), monoclonal antibodies targeted against T cells (207,208) humanized anti-CD4 antibodies (18), alemtuzumab (CAMPATH-IH), a monoclonal antibody directed against CD52 (81,209), 15-deoxyspergualin (210,211), and etoposide (180,212), and autologous hematopoietic stem cell transplants (213), but data are limited to a few cases in uncontrolled trials. [Pg.628]

See other pages where Humanized monoclonal antibodies Campath is mentioned: [Pg.299]    [Pg.299]    [Pg.1420]    [Pg.2382]    [Pg.8]    [Pg.222]    [Pg.210]    [Pg.692]    [Pg.15]    [Pg.129]   
See also in sourсe #XX -- [ Pg.430 ]



SEARCH



Antibodies humanization

Campath

Humanized antibodies

Humanized monoclonal antibodies

Monoclonal antibodies Human

Monoclonal human

Monoclonal humanized

© 2024 chempedia.info