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Prostacyclin synthase

PGHS, prostaglandin endoperoxide H synthase PGI2, prostacycline synthase... [Pg.32]

Peroxynitrite reacts with heme proteins such as prostacycline synthase (PGI2), microperoxidase, and the heme thiolate protein P450 to form a ferryl nitrogen dioxide complex as an intermediate [120]. Peroxynitrite also reacts with acetaldehyde with the rate constant of 680 1 mol 1 s" 1 forming a hypothetical adduct, which is decomposed into acetate, formate, and methyl radicals [121]. The oxidation of NADH and NADPH by peroxynitrite most certainly occurs by free radical mechanism [122,123], Kirsch and de Groot [122] concluded that peroxynitrite oxidized NADH by a one-electron transfer mechanism to form NAD and superoxide ... [Pg.704]

Todaka T, Yokoyama C, Yanamoto H, Hashimoto N, Nagata I, Tsukahara T, Hara S, Hatae T, Morishita R, Aoki M, Ogihara T, Kaneda Y, Tanabe T (1999) Gene transfer of human prostacyclin synthase prevents neointimal formation after carotid balloon injury in rats. Stroke 30 419-426... [Pg.246]

Mehl M, Bidmon HJ, Hilbig H, ZiUes K, Dringen R, et al. 1999. Prostacyclin synthase is localized in rat, bovine and human neuronal brain cells. Neurosci Fett 271 187-190. [Pg.87]

Siegle I, Klein T, Zou MH, Fritz P, Komhoff M. 2000. Distribution and cellular localization of prostacyclin synthase in human brain. J Histochem Cytochem 48 631-641. [Pg.89]

Tone Y, Inoue H, Hara S, Yokoyama C, Hatae T, et al. 1997. The regional distribution and cellular localization of mRNA encoding rat prostacyclin synthase. Eur J Cell Biol... [Pg.90]

Poole EM, Bigler J, Whitton J, Sibert JG, Potter JD, Ulrich CM. (2006) Prostacyclin synthase and arachidonate 5-hpoxygenase polymorphisms and risk of colorectal polyps. Cancer Epidemiol Biomarkers Prev. 15, 502-508. [Pg.375]

Marnett LJ, Siedlik PH, Ochs RC, et al. Mechanism of prostaglandin H synthase and prostacyclin synthase by the... [Pg.76]

Cooke, C.L., and Davidge, S.T. 2002. Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells. Am J Physiol Cell Physiol 282 C395-C402. [Pg.205]

CYP8 2 2 Prostacyclin synthase, bile-acid synthesis... [Pg.157]

Prostacyclin and thromboxane-A are derived from arachidonic acid which is a constituent of cell walls, both platelet and endothelial. Cyclooxygenase (COX, PGH synthase), an enzyme present in cells at both sites, converts arachidonic acid to cyclic endoperoxides which are further metabolised by prostacyclin synthase to prostacyclin in the endotheliiun and by thromboxane synthase to thromboxane-A in platelets. Thus prostacyclin is principally... [Pg.581]

Finally the lipoperoxidation process can be fully enzymatic and this is carried out by heme-containing cyclooxigenases (prostaglandin-, tromboxan- and prostacyclin-synthases) or ferrous ione-containing lipoxygenases which are oxidized arachidonic acid and another PUFA by means of free radical mechanism [4,5] as can be seen in Figure 2. [Pg.10]

Prostacyclin (PGI2) is an active and unstable metabolite (rj/2 = 3 minutes at 37°C and pH 7.5) formed from PGH2 by prostacyclin synthase. PGI2 has a double-ring structure and is converted by nonenzymatic hydrolysis to 6-keto-PGF] (Figure 18-22). [Pg.395]

Tuder RM, Cool CD, Geraci MW, et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 1999 159 1925-32. [Pg.162]

P450 8 Family P450 8A Subfamily CYP8A1 Prostacyclin synthase)... [Pg.438]

Wu KK, Liou JY. Cellular and molecular biology of prostacyclin synthase. Biochem Biophys Res Commun. 338 (2005) 45-52. [Pg.168]

See other pages where Prostacyclin synthase is mentioned: [Pg.924]    [Pg.52]    [Pg.67]    [Pg.67]    [Pg.67]    [Pg.518]    [Pg.360]    [Pg.577]    [Pg.774]    [Pg.189]    [Pg.39]    [Pg.1208]    [Pg.93]    [Pg.356]    [Pg.599]    [Pg.924]    [Pg.88]    [Pg.273]    [Pg.643]    [Pg.341]    [Pg.343]    [Pg.290]    [Pg.147]    [Pg.152]    [Pg.334]    [Pg.369]    [Pg.379]   
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CYP8A1 (Prostacyclin Synthase)

PGIS, Prostacyclin synthase

Prostacyclin

Prostacyclin synthase , tyrosine

Prostacyclin synthase , tyrosine nitration

Prostacycline

Prostacyclines

Prostacyclins

Synthases prostacyclin

Synthases prostacyclin

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