Human bone implications

Lazarus, H. M., Haynesworth, S. E., Gerson, S. L., Rosenthal,N. S., and Caplan,A. I. (1995), Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells) Implications for therapeutic use, Bone Marrow Transplant., 16(4), 557-564. 

Banfi, A., Muragha, A., Dozin, B., Mastrogiacomo, M., Cancedda, R., and Quarto, R. 2000. Prohferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells Implications for their use in ceU therapy. Exp Hematol, 28, 707-15. 

Richards, M.P., Fuller, B.T. and Hedges, R.E.M. (2001). Sulphur isotopic variation in ancient bone collagen from Europe implications for human palaeodiet, residence mobility, and modem pollutant studies. Earth and Planetary Science Letters 191 185-190. 

Osteoporosis, decrease in bone mass, and osteomalacia, decrease in bone mineralization, may occur in aging humans, sometimes concurrently within the same individual. Various nutritional, hormonal, iatrogenic, physical and circulatory factors have been implicated as influencing bone health (1). ... 

Larochelle A, Vormoor J, Hanenberg H, et al. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow implications for gene therapy. Nat Med. 1996 2 1329-1337. 

SAFETY PROFILE Poison by intraperitoneal route. Moderately toxic by ingestion, subcutaneous, and intravenous routes. Human teratogenic effects by unspecified route developmental abnormalities of the blood and lymphatic systems (including the spleen and bone marrow). Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of NOx and SOx. 

Gleave, M., Hsieh, J. T., von Eschenbach, A. C. and Chung, L. W. (1992). Prostate and bone fibroblasts induce human prostate cancer growth in vivo implications for bidirectional tumor-stromal cell interaction in prostate carcinoma growth and metastasis. J. Urol. 147, 1151-1159. 

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