Hot-melt extruded granules

Fig. 6 Influence of the granule particle size on the theophylline release properties of the tablets containing hot-melt extruded granules (n = 3). Tablets 20% extruded granules (Formula 3 25% theophylline, 2% PEG, and 73% PVAc), 79.5% Avicel PH200, and 0.5% magnesium stearate ( ) Less than 125 pm (i) 180-212 pm (a) 300 25 pm (O) 500-600 pm. (From Ref. l)...

Table 8 Release of acetaminophen from hot-melt extruded granules and tablets prepared from hot-melt extruded granules containing poly(ethylene glycol) 6000 as a thermal binder in 900ml of 50mM phosphate buffer (pH 5.8) at 37°C and a paddle speed of 50rpm...

McGinity J, Repka M. Hot melt extruded films. Drug Deliv Technol 2004 4(7) 40-47. Sood A, Ashokraj Y, Panchagnula R. Use of extrusion spenronization to develop controlled release dosage forms for diltiazem hydrochloride. Pharm Tech 2004 April 62-85. Jalal IM, Malinowski HJ, Smith WE. Tablet granulations composed of spherical-shaped particles. J Pharm Sci 1972 61 1466-1468. 

Matrix minitablets based on starch/microcrystalline wax mixtures were prepared by melt granulation in a hot-stage screw extruder, followed by milling and compression.f This technique was preferred over the production of pellets. 

In a typical procedure for reclamation, the LC polyester composite is first granulated into small pieces suitable for extrusion. The granulated composite is, then, mixed with dicumyl peroxide and fed into the extruder. The melt is extruded into a heated mineral oil bath. This solution is stirred vigorously during the entire batch process. The other component (PP) of the composite dissolves in hot oil and the chopped pieces of LC polyester recovered by centrifuging. The remaining oily pieces are then boiled in kerosene to remove the mineral oil. After decanting kerosene/mineral oil solution the LC polyester is washed with hexane to dissolve the kerosene and dried in convection oven. Almost 97% pure LC polyester is reclaimed [150]. 

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