Host selection mechanisms

The selective stimulation of these cells is of importance because they are the most active effector cells in host defense mechanisms against bacterial and viral infections. 

As a final comment, when female social parasites operate as inquilines and enter host colonies mimicking the chemical signature of their hosts, the mechanism of matching has been reported to be incredibly sophisticated in certain cases each parasite female is able to mimic the chemical signature of exactly her own host colony (e.g., Sledge et al., 2001), occasionally to the point that parasite queens and host workers are more similar to one another than conspecific queens and workers are in unparasitized control colonies (Franks et al., 1990). In this respect, chemical mimicry is a wonderful example of the power of natural selection in shaping the precision of adaptation. 

Cloning and Establishment of the Recombinant Cell Lines. Depending on the methods to be used to transfer a final gene construct or isolated gene fragments into its host, the mechanism of transfer, the copy number, and the physical state of the final construct inside the host cell should be provided. In addition, the amplification of the gene construct, if applicable, the selection of the recombinant cell clone, and the establishment of the seed should be completely described. 

A more specific approach to delivering agents to biological hosts is to incorporate some selectivity mechanism - this is known as targeted delivery. Selective delivery can be achieved by controlling the size of the polymer particle (vector), or through some chemical functionality on the particle surface that is recognised by the host. 

Renwick, j. a. a.. Comparative mechanisms of host selection by insects attacking pine trees and crucifers, in Chemical Mediation of Coevolution (K, C. Spencer, ed.), 303-316, Academic Press, San Diego, CA, 1988. 

Various aspects of the physico chemical properties of organic inclusion compounds have been considered. Analysis of their thermal stability and kinetics of formation and decomposition yield a better understanding of their reactivity. Their mechanism of host selectivity is driven by the process of molecular recognition and can be elucidated by analyzing the secondary interactions responsible for their supramolecular structure. 

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