Hormone chemistry

Parathyroid Hormone Chemistry, Biosynthesis, and Mode of Action John T. Potts, Jr., Henry M. Kronenberg, and Michael Rosenblatt... 

Fertility reduction was zero in the low-dose group, 25% at 0.01 Gy, and 66% at 0.1 Gy. Primary sites of damage were tubuli of the testes and spermatogonia. The high-dose group also had altered serum hormone chemistry after 30 days that persisted for 180 days... 

Riddiford, L.M. In Insect Juvenile Hormone Chemistry and Action J.J. Menn and M. Beroza, Eds. Academic Press New York, 1972 pp. 95-111. 

Rao KR (2001) Crustacean pigmentary-effector hormones chemistry and functions of RPCH, PDH, and related peptides. Am Zool 41 364-379... 

With an adenyl cyclase system, the consequence of events occurring at the receptor may be observed directly by following the production of cyclic AMP rather than by following some fxmctional parameter such as muscle contraction which is at least several steps removed from the receptor and is, therefore, subject to other control mechanisms. Furthermore, recent advances in hormone chemistry and the study of biological membranes indicate that several technical obstacles in the study of adenyl cyclase systems will be overcome within the next few years. 

Menn, J. J., and Beroza, M. (Eds.), Insect Juvenile Hormones Chemistry and Action, Academic Press, New York, 1972. 

R B Woodward was one of the leading organic chemists of the middle part of the twenti eth century Known pnmanly for his achievements in the synthesis of complex natural products he was awarded the Nobel Pnze in chemistry in 1965 He entered Massachusetts Institute of Tech nology as a 16 year old freshman in 1933 and four years later was awarded the Ph D While a student there he earned out a synthesis of estrone a female sex hormone The early stages of Woodward s estrone synthesis required the conversion of m methoxybenzaldehyde to m methoxy benzyl cyanide which was accomplished in three steps... 

Synthesis. In contrast to pituitary hormones, which usually can be obtained in pure form only after extraction from animal tissues, brain oligopeptides are readily available because of their small size. The synthetic repHca represents the most economical and readily accessible source for the oligopeptides. Two techniques are available for laboratory synthesis of oligopeptides, ie, solution chemistry and soHd-phase peptide synthesis (SPPS). 

The modification and enhancement of biological activity of drugs and hormones by fluorination represent one of the most fruitful recent developments in medicinal chemistry. Its first successes and most interesting subsequent developments were in the steroid field. Almost every new technique of introducing fluorine into organic compounds has been applied in this area and, as a result of both the gross and subtle chemical differences which steroids display at different locations of the nucleus, has produced a wealth of new chemistry. 

By the turn of the century the theory of chemical mediation of physiologic responses had gained some currency. There ensued in some laboratories an intense search for endogenous chemical modifiers of bodily responses. The first such agent to be isolated from mammalian tissue was the ubiquitous hormone, epinephrine—at that time known as adrenaline. This compound has played an important role in pharmacology as well as in medicinal chemistry. 

Chemistry and Physiology of Abscisin II, an Abscission-Accelerating Hormone... 

Organic Chemistry of Hormones Laboratory, College of France, 75231, Paris, Cedex05. 

Classical or conventional pharmaceutical agents in combination with lactide/glycolide polymers have been widely studied since about 1973. In general, these compounds are bioactive agents usually produced by synthetic chemistry, with molecular weights of less than a few hundred and relatively stable structures. Examples include steroid hormones, antibiotics, narcotic antagonists, anticancer agents, and anesthetics. 

Porath, J, Some Recently Developed Fractionation Procedures and Their Application to Peptide and Protein Hormones, Pure and Applied Chemistry 6, 233, 1963. 

Arnaud, C. D. Brewer, H. B. Jr. "Parathyroid Hormone Structure and Immunoheterogenelty" In Methods In Radioimmunoassay, Toxicology and Related Areas". Progress In Analytical Chemistry, pp. 45-75, Vol. 8, Simmons, I. L. and Ewing, 6. W., Editors, Plenum Press, New York and London, 1974. 

---