Homidium

Used in the separation and determination of nucleic acids homidium bromide [123945-8] 21 20 3... 

In rats, isometamidium is poorly absorbed from the gastrointestinal tract, approximately 99% of an oral dose being excreted in the feces. A similar absorption/excretion profile is exhibited by homidium, one of the four major impurities of the commercial product that normally contains about 70% of pure... 

Trypanocidal activity of phenanthridine derivatives was discovered in 1938 when phenidium (71) was tested versus T. congolense in mice. Dimidium (72) was quickly found more efficacious when both compounds were introduced for field use. However, for cattle, dimidium (72) is a relatively toxic substance. The discovery that homidium (73) is 10 to 50 times more potent as a trypanocide as well as less toxic to the host led to its introduction and continued use at a dose level of 1 mg kg-1. 

Colour Test. The following test is performed on homidium nitrate (see page 128) Mandelin s Test—yellow. 

Homidium Bromide 407.0 Thioridazine Hydrochloride 421.9 Bamifylline Hydrochloride... 

Holarrhena antidysenterica, 493 Holocaine, 869 Holopon, 675 Homapin, 661 Homat, 660 Homatropine, 660 Homatropine hydrobromide, 660 Homatropine methobromide, 661 Homatropine methylbromide, 661 Homidium bromide, 661 Homochlorcyclizine, 661... 

SYNS 3,8-DIAMINO-5-ETHYI 6-PHENYLPHENAN-THRIDINIUM BROMIDE 2.7-DIAMINO-9-PHENYL-10-ETHYLPHENANTHRIDINIUM BROMIDE 2,7-DI-AMINO-9-PHENYLPHENANTHRIDINEETHOBROMIDE DROMILAC ETHIDIUMBRORDDE HOMIDIUM BROMIDE RD 1572... 

Trypanosomiasis Trypanosoma spp. Tartar emetic, suramin, quinapyra-mine, homidium chloride, dimi-nazene, isometamidium chloride. 

A few quaternary salts have been found to be valuable in the treatment of try-ponosomiasis. These include metamidium (39), homidium (40), pyrithidium (41) and quinapyramine (42) [44]. 

Under carefully controlled conditions the diazonium salt (358) was coupled with homidium chloride (360) to give the trypanocide isometamidium (361) Scheme 5.82.) [485, 486], Isometamidium chloride is exceptionally potent against Trypanosoma congolense [482], Its pharmacology has been reviewed [487],... 

For the trypanosomiasis of quadrapeds, that causes such large economic loss in Central Africa, a single injection of an aminophenanthridinium salt can effect a cure, in horses, cattle, and camels (Browning a/., 1938 Carmichael and Bell, 1944). [See the review by Walls (1951) who did the first syntheses, and maintained interest in phenanthridines during a long period of neglect.] Homidium 10.23), better known under its trade-name Ethidium , seems the best of these phenanthridine trypanocides. Quinapyramine (7f .29) is used as a prophylactic (Wilson, 1949). For more on trypanosomiasis, see Sections 1.1 (p.9) and 10.3.5. 

Substance Ethidium bromide (Dromilac, homidium bromide) CAS 1239-45-8... 

The concept of intercalation was originally proposed by Lerman [48] to explain the binding of aromatic planar molecules such as aminoacridines, exemplified by proflavine (la), and later phenanthridines, such as homidium bromide (ethidium 2b) ... 

Homidium Bromide, B.Vet.C. Imipramine Hydrochloride Lucanthone Hydrochloride, B.P. 

---