Homatropine methylbromide

Homatropine methylbromide is the quaternary derivative of homatropine. It is less potent than atropine in antimuscarinic activity, but it is four times more potent as a ganglionic blocking agent. It is available in some combination products intended for relief of gastrointestinal spasm. 

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Holograms, silver and, 22 639, 657-658 Holographic applications, spectrally sensitized materials for, 9 519 Holographic interferometry, 19 588-589 Holography, optical, 27 421 Holst, Axel, 25 747 Homatropine hydrobromide, 4 360t Homatropine methylbromide, 4 360t Home desalinators, 26 55 Home scrap, 23 261, 262 Home water softeners, 22 818-819 Homobenzoate esters, aroma chemicals, 3 257... 

Butylscopolamine and methscopolamine bromide, quaternary ammonium derivatives of scopolamine without its central actions and homatropine methylbromide, a quaternary derivative of homatropine, are less potent than atropine in antimus-carinic activity. They are used for their antispasmodic action in gastroenterology. The usual oral doses act for 6-8 hours. However, the quaternary ammonium derivatives are poorly absorbed after an oral dose and their eficacy is therefore very variable. Only parenteral administrations are recommended. 

Synonyms. Homatropine Methylbromide Methylhomatro-pinium Bromide. 

Holarrhena antidysenterica, 493 Holocaine, 869 Holopon, 675 Homapin, 661 Homat, 660 Homatropine, 660 Homatropine hydrobromide, 660 Homatropine methobromide, 661 Homatropine methylbromide, 661 Homidium bromide, 661 Homochlorcyclizine, 661... 

Homatropine Methylbromide, USP. Homatropini methylbromidc. 3a-hydroxy-8-methyl-1 aN.Sa/f-tropanium bromide mandelate (Novatropine, Mesopin), occurs as a bitter. white, odorless powder and is affected by light. Tbe compound is readily soluble in water and alcohol but insoluble in ether. The pH of a 1% solution is 5.9 and that of a 10% solution is 4.5. Although a solution of the compound yields a precipitate with alkaloidal reagents, such as mercuric potassium iodide test solution, addition of alkali hydroxides or carbonates does not cause the precipitate thil occurs with nonquatemary nitrogen salts (c.g.. atropine, homatropine). 

Homatropine methylbromide is transported poorly aens-the blood-brain barrier because of its quaternary ammonium group and, therefore, has far fewer stimulant properties than atropine. It does have all the characteristic peripheral parasympathetic depressant propterties of atropin and is u.sed to reduce oversecretion and to relieve GI spasms. 

Homatropine (9) is prepared by evaporating tropine with mandelic and hydrochloric acids. Homatropine methylbromide (14) may... 

L.S. Canaes, O.D. Leite, O. Fatibello-Filho, Flow-injection turbidimetric determination of homatropine methylbromide in pharmaceutical formulations using silicotungstic acid as precipitant reagent, Talanta 69 (2006) 239. 

Homatropine methylbromide Ipratropium Isopropamide iodine Methantheline bromide Methscopolamine bromide... 

Hydrocodone bitartrate/homatropine methylbromide is an antitussive combination. Hydrocodone suppresses the cough reflex stimulates opiate receptors iu the CNS and peripherally blocks pain impulse geueratiou. Atropine inhibits action of acetylcholine or other cholinergic stimuli at postgauglionic cholinergic receptors. They are used for symptomatic relief of cough. 

Hexachlorophene Histamine dihydrochloride L-Histidine monohydrochloride Homatropine methylbromide Hydrocortisone Hydrocortisone acetate Hydrocortisone sodium succinate... 

The assay of the alkaloidal base in this salt follows the conventional lines of extraction with chloroform from ammoniacal solution and titration of the dried alkaloid using methyl red as indicator. 1 ml 0 05N acid = 0 01781 g CieHgjOaNjHBr. It can be assayed by non-aqueous titration (p. 792) using 0 5 g. 1 ml 0 1 N perchloric acid — 0 03563 g. Homatropine methylbromide, Ci7H2403NBr, Mol. Wt. 370 3 can also be assayed by this method. 1 ml 0 1 N perchloric acid == 0 03703 g. 

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