Piperazine citrate

Piperazine citrate is typically used as a secondary agent in ascariasis (roundworm) and enterobiasis (pin-worm) infections (see Table 35-5). This drug appears [Pg.559]

Piperazine citrate is produced from piperazine that is first manufactured by the cyclization of ethylene dibromide with alcoholic ammonia at 100°C. The citrate is formed in aqueous solution and crystallized out. [Pg.408]

Piperazine citrate is used as an anthelmintic in the treatment of infections caused by pinworms and roundworms. It is also employed by veterinarians against various worms infecting domestic animals, including chickens. [Pg.408]

Piperazine citrate Tabs. 0.2 (= Piperazine Hydrate) 105 Each g of dipicrate residue = 0.3568 g of (C4H10N2)3, 2C6Hs07... [Pg.188]

The following drugs also are indicated in Ascariasis. Piperazine citrate (if intestinal or biliary obstruction) thiabendazole. [Pg.1930]

Infestations with parasitic worms and flukes are widespread both in humans and in animals, and their treatment requires drugs that act in a different manner from antibacterial and antiprotozoal agents. It is desirable for worms to be expelled from the body intact since the presence of dead worms in the tissues can provoke severe reactions. Such reactions are seen when filarial worms which circulate in the blood and lymph are killed by diethylcar-bamazine (264). Intestinal worms may be expelled when they are paralyzed by neuromuscular blockers such as piperazine citrate or pyrantel (265), or their metabolism may be disrupted by the anthelmintic drugs tetramisole and thiabendazole (266) which inhibit fumarate reductase, or mebendazole (267) which prevents glucose uptake by the worms. The anthelmintic activity of tetramisole is due to its laevo isomer levamisole (186). The dextro isomer has antidepressant activity. [Pg.181]

Ascariasis (roundworm) Albendazole, mebendazole, pyrantel pamoate Piperazine citrate... [Pg.558]

Chemicals known as piperazines have industrial applications worldwide, and it is legal to purchase bulk quantities of these chemicals on the Internet for this purpose. By changing chemical groups added to the basic piperazine skeletal structure, different chemicals can be formed that vary considerably in their industrial, medical, and mind-altering properties. Piperazine citrate and related compounds destroy intestinal worms, making these chemicals useful in both medical and veterinary preparations. Other medicinal and mind-altering qualities of piperazines are being exploited as possible treatments of depression, psychosis, Alzheimer s disease, and tumors. [Pg.77]

Since the early 1950s, piperazines have been widely used in veterinary medicine as anthelminthic drugs, which rid the lower intestinal tract of parasitic worms. In humans, diethylcarbamazine and piperazine citrate serve a similar function and are used to treat pinworm and roundworm infestations in adults and children. While... [Pg.78]

Piperazine Citrate. Accessed 4/17/02. [Pg.81]

Oral piperazine citrate tablets equivalent to 250 mg of the hexahydrate piperazine citrate syrup equivalent to 500 mg of the hexahydrate per 5 mL... [Pg.1239]

Infra-red Spectrum. Principal peaks at wavenumbers 1592, 955, 870, 1080, 1055, 1115 (piperazine citrate, KBrdisk). [Pg.907]

Pyrrobutamine Phosphate Thiothixene Hydrochloride 642.7 Piperazine Citrate... [Pg.1083]

Homatropine Methobromide Oxyphenonium Bromide Phenacaine Hydrochloride Piperazine Citrate 190d Ascorbic Acid... [Pg.1090]

Sulphadimethoxine Suprofen Lysergic Acid Methapyrilene Piperazine Citrate Viprynium Embonate Phenylephrine Hydrochloride Chloroprocaine Chloropyrilene Dropropizine Methylprednisolone Oxymetazoline Hydrochloride Penicillamine Clothiapine Cyclothiazide Aloxiprin... [Pg.1147]

Onuaguluchi G, Mezue WC. Some effects of piperazine citrate on skeletal muscle and central nervous system. Arch Int Pharmacodyn Ther 1987 290(1) 104-16. [Pg.2841]

Piperazine is also a drug of choice for treating pinworm infections in children and adults. A dose of 2-2.5 g of piperazine given daily for 14 days gives nearly 100% cures, while a dose of 50-75 mg/kg (maximum 0.5-3g) of piperazine citrate given for 7-14 days produces 85-100% elimination of . vermicularis in man with little or no toxicity [52-54,56,57]. Piperazine and its salts show poor activity against whipworms, Trichuris trichiura in man [63,64]. [Pg.158]

Piperazine Salts. Piperazine citrate is highly effective against bothM. lumbricoides (large roundworm) and E. vermicularis (pinworm). A large number of substituted piperazine derivatives exhibit anthelmintic activity however, only diethylcarbamazine (9) is used clinically (26). [Pg.245]

Salts of piperazine (citrate, phosphate, adipate) or its hexahydrate are used as anthelminitics. The piperazine ring is frequently used as a building block for pharmaceuticals. Benzhydrylpiperazines, such as cinnarizine 8 and its difluoro analogue flunarizine 9, possess considerable activity as peripheral and cerebral vasodilators. Hydroxyzine 10 is used as a tranquilizer ... [Pg.424]

Thus piperazine citrate used for the treatment of pinworms (threadworms) can produce an allergic drug eruption in ethylenediamine-sensitive individuals (Burry 1978). Cross-reactions can occur in chemists and laboratory technicians who handle both of these chemicals (Calnan 1975). [Pg.383]

Burry JN (1978) Ethylenediamine sensitivity with a systemic reaction to piperazine citrate. Contact Dermatitis 4 380... [Pg.389]

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