Hoffmann-La Roche company

The checkers obtained methyl vinyl ketone from Hoffmann-La Roche Company and chlcrotrimethylsilane from Aldrich Chemical Company, Inc. Both were distilled from calcium hydride. Triethylamine obtained from J. T. Baker Chemical Company was distilled from calcium hydride, and dimethylformamide from Fisher Scientific Company was used from a freshly opened bottle. 

Department of Vitamin and Nutrition Research and Section for Mathematical Statistics, F. Hoffmann La Roche Company, Limited, CH-4002,... 

Consider the structure of diazepam, first marketed by the Hoffmann-La Roche Company under the trade name Valium ... 

Fine chemical companies are generally either small and privately held or divisions of larger companies, such as Eastman Fine Chemicals (United States) and Lonza (Switzerland). Examples of large public fife science companies, which market fine chemicals as a subsidiary activity to their production for captive use, are Hoffmann-La Roche, Sandoz, and Boehringer Ingelheim, which produce and market bulk vitamins and liquid crystal intermediates, dyestuff intermediates, and bulk active ingredients, respectively. Table 3 fists some representative companies having an important fine chemical business. 

The alkyne hydrogenation reaction has been explored extensively by the Hoffmann-La Roche pharmaceutical company, where it is used in the commercial synthesis of vitamin A. The cis isomer of vitamin A produced on hydrogenation is converted to the trans isomer by heating. 

In addition to rophies or roofies, Rohypnol is known by a multitude of other street names, including roach or roche, a direct reference to Hoffmann-La Roche, the pharmaceutical company that manufactures the drug. In some circles, being under the influence of Rohypnol is referred to as being reached out. Another street name that is sometimes used is R-2, a reference to the pills themselves, which are imprinted with a 1 or 2 inside a circle to identify whether they are a 1-mil-ligram or 2-milligram dose. Other names may include roachies, La Rocha, rope, rib, and ruffies. 

G.B. Patent No. 1,484,481 Sept. 11, 1974 F. Hoffmann-La Roche and CO., Aktiengesellschaft, Swiss Company, 124-184 Grenzacherstrasse Basle, Switzerland... 

F. Hoffmann-La Roche and Company, Ltd., Basle, Switzerland. Deceased. 

Thus terpenes (a-pinene, (3-pinene) can be produced from natural turpentine, as is traditionally done by rosin producers such as Hercules, Glidden, or Union Camp in the United States, or on a smaller scale in France by Societe des Derives Resiniques et Terpeniques, DRT. BASF and Hoffmann-La Roche, however, have demonstrated that starting from acetylene or isobutylene, terpene chemicals can be synthetically reproduced. Both companies are able to produce both their vitamins and perfume bases in this way. 

The authors owe a great debt of gratitude to the companies F. Hoffmann - La Roche AG and Gebr. SULZER AG and the KWF ( Kommision zur Forderung der wissenschaftlichen Forschung ) for their generous financial support of this work. 

The chemical library of a company comprises the real and tangible history of all the projects they have worked on, and all the compounds they made to hit those projects targets. So, if you work at Hoffmann La Roche which invented Valium and many other benzodiazepine drugs, then... 

Vitamin C was the first vitamin to be manufactured by chemical synthesis on an industrial scale. Major suppHers of vitamin C are Hoffmann-La Roche, BASF, Takeda, E. Merck, and various companies in China. Additional production occurs in Eastern Europe and India. 

Wodd production in the late 1990s of both natural and synthetic forms of vitamin E is estimated at 22,000 metric tons and growth is expected to keep pace with increasing need. The 1993 U.S. production was 14,096 metric tons (47) with an additional 1080 metric tons from imports. The principal U.S. producers of the natural form are Eastman Chemical Company, Archer Daniels Midland Company, and Henkel, and of synthetic vitamin E, HofEmann-La Roche and BASF. International producers include Hoffmann-La Roche, BASF, Eisai, and Rh< ne-Poulenc. 

Hoffmann-La Roche Inc., 166 Lilly Research Laboratories, 190 Monsanto Agricultural Company, 92 North Carolina State University, 14 Research Triangle Institute, 14 Smith, Kline and French Research Laboratories, 124 TNO-CIVO Institutes, 179 U.S. Environmental Protection Agency, 62 University of California, 270 Vestec Corporation, 215... 

C. E. Shafer, Eli Lilly and Company, Indianapolis, Indiana C. Shearer, Wyeth Laboratories, Philadelphia, Pennsylvania R, J. Simmons, Eli Lilly and Company, Indianapolis, Indiana L. H. Sternbach, Hoffmann-La Roche Inc., Nutley, New Jersey... 

In Europe, as Table 1.2 illustrates, the German and Swiss leaders were the Rhine Valley chemical companies, whose evolution has been sketched above. The British companies became significant competitors after World War II, but France s Rhone-Poulenc failed to become a factor in world markets. The most successful European pharmaceutical company of all in terms of revenues and profits was F. Hoffmann-La Roche (now Roche Holding), established in 1894 in Basel, Switzerland, the headquarters site of the three Swiss chemical companies listed in Table 1.1. 

After the merger, Ciba-Geigy grew much more steadily from internal investment than from acquisitions. By 1978 the sales of its U.S. subsidiaries had reached 1 billion and six years later, in 1984, the company purchased two U.S. agrichemicals companies, Airwick Industries and Funk Seeds. In 1990 it acquired the agricultural chemical business of its Swiss neighbor, F. Hoffmann-La Roche. 

After the war Merck and his company maintained close personal and technical ties with its former parent company as it began to enhance its own technical and functional capabilities. Following the construction of an extensive laboratory of its own in 1933, Merck started to commercialize vitamins—B-1, at first, then B-2, followed by B-6, C, K, and culminating in 1944 with vitamin B-12, a treatment for pernicious anemia. By the end of World War II, Merck had become the largest producer of vitamins in the United States and second only to the Swiss leader, R Hoffmann-La Roche, worldwide. 

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