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Drugs benzodiazepine

Cooper TB. 1988. Gas-liquid chromatography of antidepressant, antipsychotic and benzodiazepine drugs in plasma and tissues. Neuromethods, Vol. 10 Analysis of Psychiatric Drugs. Boulton AA, Baker GB, Coutts RT, editors. New Jersey Humana Press pp. 65-98. [Pg.13]

Nonisotopic receptor assay for benzodiazepine drugs using time-resolved fluorometry. Anal. Chem. 1995, 67, 2655-2658. [Pg.280]

Although it is widely claimed that the benzodiazepine drugs have a specific calming or anxiolytic effect, their most prominent and easily quantifiable action is central nervous system depression. In very low therapeutic doses, this depression manifests as relief of anxiety that is often accompanied by a feeling of sluggishness or drowsiness. As the dose is increased, the degree of depression is intensified such that muscle relaxation, hyp-... [Pg.358]

Nevertheless, the GABAergic properties of benzodiazepines remain their most important clinical application. Over the past 30 years, the most widely used benzodiazepine drug has been diazepam (1.6). It is an anxiolytic, sedative, and muscle relaxant the anxious, depressed person becomes more outgoing and relaxed. There have been many diazepam analogs. Oxazepam (4.177) and lorazepam (4.178) have similar effects. Temazepam (4.179), flunitrazepam (4.180), and flurazepam (4.181) are useful sedative-hypnotics. Clonazepam (4.182) is a clinically useful anticonvulsant. Brotizolam (4.183), a novel benzodiazepine analog, seems to be an effective sedative-hypnotic. Midazolam (4.184) is an imidazolo-benzodiazepine that is water soluble and thus easily injectable. It is a hypnotic sedative with marked amnestic (i.e., memory loss) properties and is used in dentistry, endoscopic procedures, and induction to anesthetics in the elderly and in... [Pg.275]

Benzodiazocines have attracted much interest as homologs of 1,4-benzodiazepine drugs, and several efficient cyclization methods have been developed. The diamine (289 R = H), available by several routes from the aminobenzophenone, cyclizes slowly in hot pyridine, but treatment of the halide (288) with ammonia leads directly to (292), perhaps by prior... [Pg.683]

Campbell AJ, Somerton DT. Benzodiazepine drug effect on body sway in elderly subjects. J din Exp Gerontol 1982 4 341-347. [Pg.308]

Many people in the United States have heard of Rohypnol (flunitrazepam), otherwise known as the date rape drug, as a result of news reports about its abuse. Rohypnol is neither actually on the market nor approved for medical use in the United States. However, it is legal and available by prescription in other parts of the world, including Mexico, South America, Asia, and Europe, where it is one of the most widely used benzodiazepine drugs. Like other benzodiazepines, it is a downer, meaning it acts as a sedative and has a depressant effect on the body s central nervous system (CNS). Other common benzodiazepine drugs include Valium, Xanax, and Halcyon. [Pg.434]

Benzodiazepine drugs can cause a range of side effects, including dizziness, confusion, and impaired motor control. Long-term benzodiazepine use can lead to physical dependence. Despite these problems, benzodiazepines have remained the standard antianxiety drugs for approximately 50 years. [Pg.372]

After the introduction of the benzodiazepine drugs in the 1960s, several studies were conducted evaluating their effects in schizophrenia. Since benzodiazepines were fairly new at the time, they did not suffer from the... [Pg.78]

Recreational drug users note the same effects. Several comment on similarities between olanzapine and quetiapine and the benzodiazepine drugs, such as diazepam (Valium), because of the intense sedation. However none report the euphoria that characterises benzodiazepine effects. One correspondent reported protracted insomnia after stopping olanzapine, comparing it to benzodiazepine withdrawal (Sixseal.com 2007). [Pg.106]

Phosphorus pentasulfide may also be converted into a powerful soluble sulfur-ization agent by reaction with butyllithium in THF, and the use of this reagent to convert the lactam function of a benzodiazepine drug 80 to the corresponding thiolactam 81 is illustrated in Protocol 20. [Pg.85]

There are more than 30 million people who take benzodiazepine drugs regularly each year more than 4 million are addicted. As with other benzodiazepines, treatment for Rohypnol dependence must be gradual, with use tapering off. [Pg.28]

Steinberg JR. Anxiety in elderly patients. A comparison of azapirones and benzodiazepines. Drugs Aging 1994 5(5) 335-45. [Pg.436]

Etifoxine is a non-benzodiazepine drug, licensed in France for psychosomatic manifestations of anxiety. [Pg.439]

The chemical library of a company comprises the real and tangible history of all the projects they have worked on, and all the compounds they made to hit those projects targets. So, if you work at Hoffmann La Roche which invented Valium and many other benzodiazepine drugs, then... [Pg.125]

Most of the biogenic benzodiazepines show distinct biological activities, which are, however, different from the tranquilizing properties of the synthetic benzodiazepine drugs. At present the most promising compound with respect to... [Pg.64]

Interestingly, asperlicin showed little or no affinity for either the central or the peripheral receptors of the classic benzodiazepine drugs (S). This indicates again the dominating role of distinct substituents that are fixed by the benzodiazepine moiety at specific spatial positions in determining the interaction with receptor structures. [Pg.94]


See other pages where Drugs benzodiazepine is mentioned: [Pg.269]    [Pg.22]    [Pg.9]    [Pg.87]    [Pg.54]    [Pg.61]    [Pg.239]    [Pg.211]    [Pg.69]    [Pg.236]    [Pg.236]    [Pg.237]    [Pg.1384]    [Pg.45]    [Pg.64]    [Pg.285]    [Pg.319]    [Pg.42]    [Pg.70]    [Pg.74]    [Pg.312]    [Pg.367]    [Pg.265]    [Pg.372]    [Pg.211]    [Pg.86]    [Pg.61]    [Pg.209]    [Pg.449]    [Pg.502]    [Pg.93]   
See also in sourсe #XX -- [ Pg.10 , Pg.11 , Pg.33 , Pg.160 , Pg.164 , Pg.167 , Pg.168 , Pg.258 , Pg.269 , Pg.448 ]




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