High-throughput techniques

The need for efficient high-throughput techniques in the production of enantiomeri-cally pure compounds is growing in parallel to the increasing structural complexity of new drug compounds [1]. 

Before we continue explicitly discussing high-throughput techniques and examples in the polymer field, we will first provide some definitions that may be... 

TDM has improved the performance of anticancer, antidementia, antidepressant, antiepileptic, anticonvulsant, antifungal, antimicrobial, antipsychotic, antiretroviral, anxiolytic, hypnotic, cardiac, addiction treatment, immunosuppressant, and mood stabilizer drags for more than 30 years.2-9 Many analytical procedures evolved as analytical techniques and instrumentation have advanced. This chapter briefly reviews the different types of analytical methods the applications of high-throughput techniques in TDM are discussed in detail. 

On the one hand, high-throughput techniques can be used to achieve more specific catalysts, while the use of conditions favoring a reduction in coke formation during the reaction (i.e., the use supercritical conditions) could also be of crucial importance in the rapid incorporation of these catalysts into industrial processes. 

SynPhase crowns may be used to perform large numbers of optimization reactions in parallel. This library of reaction conditions may be analyzed by assaying product purities after cleavage from the solid phase using high-throughput techniques such as HPLC and ESMS. Overall, this approach can greatly reduce the time required for this critical step of compound library development. 

High-throughput techniques will not only speed up the search, but in this area, as in other aspects of toxicology, bioinformatics will be necessary, not only for correlating the data from many sources but also for reducing it for practical applications. 

Figure 6.1 Basic concept of the application of FTIR imaging as a high-throughput technique. Placing multiple samples in the field of view of the imaging spectrometer allows the collection of a single dataset that contains information from all samples. Reprinted with permission from ACS.

To remove some of the limitations imposed by the approaches mentioned above, Fourier transform infrared (FTIR) imaging has been developed as a high-throughput technique for the study of heterogeneous catalysts.21,22 By combining an array... 

The choice of using low-, medium- or high-throughput techniques depends on the particular question being dealt with and the required outcome of the study. Each of these three levels is considered individually in this section, although the boundaries among the three levels cannot be simply defined. 

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