High-throughput analytical techniques, for

Congreve, M. S., and Jamieson, C. (2002), High-throughput analytical techniques for reaction optimization, Drug Discovery Today, 2,139-142. 

R Wei, H Lee, LYT Li, JN Kryanos. Development of a high throughput analytical technique for compound permeability studies using Caco-2 Cells and HPLC/MS. Proceedings of the 47th American Society for Mass Spectrometry Conference, Dallas, TX, 1999. 

Congreve, M.S. Jamieson, C. High-throughput Analytical Techniques for Reaction Optimization, Drug Discovery Today 7,139-142 (2002). 

LL High-Throughput Analytical Techniques for Comhinatorial Library Analysis... 

A high-throughput analytical technique such as NMR has promise of adoption to investigate the metabolite content of vegetables. This information combined with multivariate statistical analysis is expected to offer a conclusive and exhaustive idea of quality discrimination and prediction with high reliability for new samples. In the field of fresh cut fruits and vegetables, demands for quality determination are increasing over the past decade. 

The ideal high-throughput analytical technique would be efficient in terms of required resources and would be scalable to accommodate an arbitrarily large number of samples. In addition, this scalability would be such that the dependence of the cost of the equipment to perform the experiments would scale in a less than linear manner as a function of the number of samples that could be studied. The only way to accomplish this is to have one or more aspects of the experimental setup utilize an array-based approach. Array detectors are massively multiplexed versions of single-element detectors composed of a rectangular grid of small detectors. The most commonly encountered examples are CCD cameras, which are used to acquire ultraviolet, visible and near-infrared (IR) photons in a parallel manner. Other examples include IR focal plane arrays (FPAs) for the collection of IR photons and channel electron multipliers for the collection of electrons. 

D. High-Throughput Analytical Techniques Used for Characterization of Combinatorial Libraries... 

In the DoE approach, first process variables are screened to determine which are important to the outcome (excipient type, percentage, mixture time, etc.). The next step is optimization, when the best settings for the important variables are determined. In particular, response surface methodologies have been successfully applied in both drug discovery and development [33]. Advances in supporting software, automated synthesis instrumentation, and high-throughput analytical techniques have led to the broader adoption of this approach in pharmaceutical discovery and chemical development laboratories [34],... 

In general, however, detailed protocols for the direct analysis of stereochemical features by mass spectrometric means have not been achieved so far. Instead, other analytical methods, such as X-ray analysis or nuclear magnetic resonance (NMR), elegantly address these issues [3]. However, with respect to the analysis of trace compounds and in the context of high-throughput analytical methods, it would be beneficial to develop tools for rapid stereochemical assays by mass spectrometric means or hyphenated techniques [4,5]. 

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