High-throughput screening chemical techniques

High Throughput Screening (HTS) Techniques Overview of Applications in Chemical Biology... 

Chemical Libraries Screening for Biologically Active Small Molecules High Throughput Screening (HTS) Techniques Overview of Proteins, Chemistry and Chemical Reactivity of Synthetic Peptides and Proteins to Elucidate Biological Function... 

High throughput screening is one of the hot topics in heterogeneous catalysis. Advanced experimental techniques have been developed to screen and develop solid catalysts for gas-phase systems. However, for catalytic three-phase systems, rapid screening has got much less attention [1-6]. Three-phase catalysis is applied in numerous industrial processes, from synthesis of fine chemicals to refining of crade oil. 

In future, two developments may be expected. On the one hand, elaborated biophysical methods will measure interactions in the cellular context and dissect complex biological patterns. On the other hand, established physico-chemical techniques mainly based on fluorescence will be utilized in high throughput screens to investigate new substances upon their interference with Ras function. 

Now with the advent of high throughput screening techniques, also known as combinatorial methodologies, pioneered by Symyx Technologies and the subject of this book, the catalyst researcher is provided with an entirely new tool which allows for experimentation to be accelerated by a factor of 102 to 104. This indeed is remarkable as is amply described and dissected in the different contributions of this book, for it is now possible to combine chemical know-how, experience, intuition and fast experimentation all at once. 

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