High resolution mass spectrometr

Kuehl, D.W., B.C. Butterworth, J. Libal, and P. Marquis. 1991. An isotope dilution high resolution gas chromatographic-high resolution mass spectrometric method for the determination of coplanar polychlorinated biphenyls application to fish and marine mammals. Chemosphere 22 849-858. 

Schuetzle, D. Computer Controlled High Resolution Mass Spectrometric Analysis of Air Pollutants. Ph.D. Thesis. Seattle University of Washington, 1972. 242 pp. 

Appel, B. R., S. M. Wall, and R. L. Knights, "Characterization of Carbonaceous Materials in Atmospheric Aerosols by High Resolution Mass Spectrometric Thermal Analysis, Adv. Environ. Sci. Technol., 10, 353-365 (1980). 

Hayes JM, Biemann K (1968) High Resolution Mass Spectrometric Investigations of the Organic Constituents of the Murray and Holbrook Chondrites. Geochim Cosmochim Acta 32 239... 

Ta ble VI contains a portion of the low-voltage, high-resolution mass spectrometric information... 

Patterson DG Jr, Hampton L, Lapeza Cr Jr, et al. 1987a. High-resolution gas chromatographic/high-resolution mass spectrometric analysis of human serum on a whole-weight and lipid basis for... 

There are several schools of thought on this topic. Some maintain that all new compounds must be analysed, whereas others say that, with the modem array of physical methods (high resolution nmr spectroscopy and high resolution soft ionization mass spectroscopy, for example) the need for combustion analysis no longer exists. Many follow a middle course and use microanalysis for crystalline compounds which are available in sufficient quantity, and high resolution mass spectrometric measurements in all other cases. The course you take will depend upon circumstances (the requirements of your supervisor or the department, for example). 

Hayes J. M. and Biemann K. (1968) High resolution mass spectrometric investigations of the organic constituents of the Murray and Holbrook chondrites. Geochim. Cosmochim. Acta 32, 239-269. 

Van Rhijn, J.A. Traag, W.A. Kulik, W. Tuinstra, L.G. Automated clean-up procedure for the gas chromatograph-ic-high-resolution mass spectrometric determination of polychlorinated dibenzo-p-dioxins and dibenzofurans in milk. J. Chromatogr. 1992, 595 (1-2), 289-299. 

In the case of completely unknown compounds, the molecular formula is a useful source of additional information it can be determined using small amounts of substance (a few micrograms) by high-resolution mass spectrometric determination of the accurate molecular mass. It provides information concerning the double-bond equivalents (the degree of unsaturation —the number of multiple bonds and rings). 

It was required that the final determination should be carried out by capillary gas chromatography with high resolution mass spectrometric detection and that two isotope... 

While the ECNI high resolution mass spectrometric method offers unmatched specificity because of the high degree of sophistication and their high cost, these instmments are not available in most analytical laboratories. In light of this, more recent efforts have gone into improving on the early ECNI low resolution mass spectrometric analytical methods. 

Beside the qualitative identification of elements the atomic emission detector provides the possibility of determination of elemental composition and empirical formulas with compound independent calibration (Wylie et al., 1990 Quimby et al., 1995). This possibility enables an identification independent from retention times and does not require authentic reference standards for calibration. For structural elucidation the element ratios have been calculated using the method of relative response factors. Triphenylarsine was used as standard. The results have been confirmed by complementary high resolution mass spectrometric investigations. Table 4 summarizes the results of selected compounds. 

Appel, B. R. 1981. Characterization of carbonaceous materials in atmospheric aerosols by high-resolution mass spectrometric thermal analysis. In G. M. Hidy, ed.. The aerosol characterization experiment. Wiley-Interscience, New York. 

Bai Y, Galetskiy D, Damoc E, Paschen C, Liu Z, Griese M, Liu S, Przybylski M. High resolution mass spectrometric alveolar proteomics Identification of surfactant... 

Clearly, high-resolution mass spectrometric data dramatically simplifies the problem of product ion assignment. The routine, automatic translation of product ion data into a maximally constrained oxidation (i.e., the substructure identified as containing the site of oxidation is the smallest possible set of atoms consistent with the observed product ions) remains an open problem at the moment, at least in the sense that no robust, generic, open-source, or commercially available solution exists. A small number of publications have presented proof-of-concept or company-internal approaches to the localization problem, either with or without high-resolution data as input. In the simplest situations, either (a) the product ion spectrum of the metabolite is identical to that of the parent drug, in which case the biotransformation is likely to be on the smallest possible neutral which is lost, or (b) the product ion spectrum of the metabolite is identical to that of the parent compound, with the exception of one, attributable, low m/z product ion shifted by the mass of... 

Ruan, Q., Ji, Q.C., Arnold, M E., Humphreys, W.G., Zhu, M. (2011) Strategy and its implications of protein bioanalysis utilizing high-resolution mass spectrometric... 

High Resolution Gas Chromatographic/ Real-Time High Resolution Mass Spectrometric Identification of Organic Acids in Human Urine Anal. Chem. 51(8) 1275-1285 (1979) CA 91 52054u... 

High resolution mass spectrometric analysis of stemoburkilline (57) showed the same molecular formula as (115,127 )-dihydrostemofoline (56), but its H-NMR data indicated the presence of an olefinic proton (S 5.5 ppm) coupled to an adjacent methine hydrogen (HIO). Extensive 2D-NMR analyses showed that stemoburkilline (57) was the C-ring opened product of stemofoline (48). Its -configuration was assigned on the basis of the assumption that 57 arises from 56 via an anti-elimination process (56). 

Schriks M, Van Leerdam JA, Van Der Linden SC, Van Der Burg B, Van Wezel AP, De Voogt P. High-resolution mass spectrometric identification and quantification of glucocorticoid compounds in various wastewaters in the Netherlands. Environ Sci Tech 2010 44(12) 4766-74. 

Washburn et al. 2001 Fournier et al. 2007). High-resolution mass spectrometric instruments have been developed for shotgun proteomic experiments (Domon and Aebersold 2006, 2010 Nilsson et al. 2010). The MS dataset is used to perform database searches using dedicated bioinformatics tools in order to achieve the identification of proteome components (Figure 10.1). 

Lewis, S., Keynon, C.N., Meili, J. and Burlingame, A.L. (1979), High resolution gas chromatographic/real-time high resolution mass spectrometric identification of organic acids in human urine. Anal. Chem., 51,1275. 

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