Alveolar proteomics

Peptide mass fingerprinting can be performed by use of MALDI-FT-ICR [94,95]. For example, Przybylski and co-woikers applied MALDI-FT-ICR to the proteomic analysis of cryoglobulins from a hepatitis C patient [96], and to alveolar proteomics associated with proteinosis and cystic fibrosis [97]. Alternatively, LC can be coupled with ESI FT-ICR for peptide mass fingerprinting [94]. Among other applications, LC coupled with ESI-FT-ICR has been used in the proteomic analysis of Escherichia coli [98], the proteomic analysis of amniotic fluid [99], the identification of brain natriuritic peptide (BNP-32) in plasma following heart failure [100], and in the molecular differentiation of ischemic and valvular heart disease [101]. 

Bai, Y. Galetskiy, D. Damoc, E. Paschen, C. Liu, Z. Giiese, M. Liu, S. Przybylski, M. High resolution mass spectrometiic alveolar proteomics Identification of surfactant protein SP-A and SP-D modifications in proteinosis and cystic fibrosis patients. Proteomics 2004,4, 2300-2309. 

Bai Y, Galetskiy D, Damoc E, Paschen C, Liu Z, Griese M, Liu S, Przybylski M. High resolution mass spectrometric alveolar proteomics Identification of surfactant... 

Wu HM, Jin M, Marsh CB (2005) Toward funcdonal proteomics of alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 288 L585-L595. 

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