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High performance liquid blood samples

Clark et al. [136] studied the excretion, distribution, and metabolism of primaquine in rats. The drug was administered intravenously, intraperitoneally, and orally and blood samples were collected at various time intervals. Primaquine was metabolized by oxidative deamination to give 8-(3-carboxy-l-methylpropylamino)-6-methoxy quinoline. The plasma levels of both primaquine and its metabolites were determined by high performance liquid chromatography. [Pg.200]

Determination of brinzolamide and its 3 principal metabolites (the N-desethyl, A -desmethoxypropyl and O-desmethyl analogs) in whole blood and plasma from clinical and pre-clinical studies was performed using high performance liquid chromatography (HPLC) with UV detection. After addition of a known amount of internal standard (AL-5138, the 4-methoxybutyl analog of brinzolamide), the sample was acidified with 50 mM sodium phosphate buffer, pH 3.0 and extracted with ethyl acetate. [Pg.78]

Figure 3.2 A scientist prepares a high-performance liquid chromatography (HPLC) machine to analyze a blood sample. The results of the test are visualized on the monitor to her right. Figure 3.2 A scientist prepares a high-performance liquid chromatography (HPLC) machine to analyze a blood sample. The results of the test are visualized on the monitor to her right.
Lennard L, Singleton HJ. High-performance liquid ehromatographie assay of the methyl and nucleotide metabolites of 6-mercaptopurine quantitation of red blood eell 6-thioguanine nueleotide, 6-thioinosinic acid, and 6-methylmercaptopurine metabolites in a single sample. J Chromatogr 1992 583 83-90. [Pg.196]

Fig. 5 High-performance liquid chromatogram of spiked human blood serum sample (after 20-fold dilution) containing 1) creatine, 2.760 min 2) creatinine, 3.615 min 3) uric acid, 5.232 min and 4) xanthine, 7.488 min. Chromatographic conditions are described in Table 2. (From Ref. [1].)... Fig. 5 High-performance liquid chromatogram of spiked human blood serum sample (after 20-fold dilution) containing 1) creatine, 2.760 min 2) creatinine, 3.615 min 3) uric acid, 5.232 min and 4) xanthine, 7.488 min. Chromatographic conditions are described in Table 2. (From Ref. [1].)...
The preferred blood sample is one collected with either K or Na salts of ethylenediaminetetraacetic acid (EDTA) as the anticoagulant. To minimize the formation of degradation products, which are especially noticeable as small bands eluting with similar retention time as Hb Ai and Hb F on high-performance liquid chromatography (HPLC) analysis, testing should be performed within 5 days of collection and samples should be stored at 4 "C. [Pg.1171]

The pharmacokinetics parameters of catechin metabolites are listed in table 7.2. Intact tea catechins, EC, ECG, EGC, and EGCG in human plasma and urine, are detected but with low concentrations. To determine the content of conjugated metabolites of catechins, blood and urine samples are treated with p-glucuronidase and sulfatase to remove the glucuonic or sulfate group prior to high-performance liquid chromatography (HPLC) analysis. [Pg.114]

Kramer-Horaczynska, F. High-performance liquid chromatographic procedures for the quantitative analysis of 15 tetracycline derivatives in small blood samples. J.Chromatogr.ScL, 1991, 29, 107-113... [Pg.535]

Bocker, R. Rapid analysis of doxycycline from biological samples by high-performance liquid chromatography. J.Chromatogr., 1980, 187, 439-441 [whole blood serum tissue mouse liver]... [Pg.542]

Flores-Murrieta, F.J. Granados-Soto, V. Hong, E. Determination of ketorolac in blood and plasma samples by high-performance liquid chromatography. Boll.Chim.Farm., 1994, 133, 588-591... [Pg.827]

Bailey, L.C. Tang, K.T. Rogozinski, B.A. The determination of 2,6-diisopropylphenol (propofol) in an oil in water emulsion dosage form by high-performance liquid chromatography and by second derivative UV spectroscopy. J.Pharm.Biomed.Anal., 1991, 9, 501-506 Chan, K. So, A.P. The measurement of propofol in human blood samples by liquid chromatography. [Pg.1188]

Inoue, K., Kawaguchi, M., Okada, F., Yoshimura, Y., and Nakazawa, H., Column-switching high-performance liquid chromatography electrospray mass spectrometry coupled with Online of extraction for the determination of mono- and di-(2-ethylhexyl) phthalate in blood samples. Anal. Bioanal. Chem., 375, 527-533, 2003. [Pg.1150]

Disposable steel needles used widely in medical practice for drawing of blood samples cannot be used for sampling blood intended for trace metal analysis. Contamination of blood samples by such needles can exceed the actual level of chromium in the sample by a factor of 100-1000. In case liquid chromatography (LC) is used for separation of species, the system inherent contamination has to be taken in account, when using high-performance liquid chromatography (HPLC) equipment (pumps, valves, columns, capillaries) made from stainless steel. [Pg.687]

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See also in sourсe #XX -- [ Pg.4 , Pg.233 ]



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