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High content analysis assays

Wilson, C.J. et al. 2006. Identification of a small molecule that induces mitotic arrest using a simplified high-content screening assay and data analysis method. J. Biomol. Screen. 11, 21-28. [Pg.155]

Since its creation around 1973, modern high-pressure liquid chromatography (HPLC) has played a dominant role in the analysis of pharmaceuticals. It is used in many different applications for example, in content uniformity assays and stability-indicating methods, for the purity profiles of drug substances, or in the analysis of drug metabolism in animals and humans. The heart of all of these assays is the HPLC column. In this chapter, we will describe the fundamental properties of HPLC columns as well as how these properties influence column performance and separation characteristics in pharmaceutical assays. [Pg.78]

Trask OJ Jr, Moore A, LeCluyse EL (2014) A micropattemed hepatocyte coculture model for assessment of hver toxicity using high-content imaging analysis. Assay Drug Dev Technol 12,16-27. [Pg.128]

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