Receptors high affinity

Watowich, S.I., et al. Crystal structures of influenza virus haemagglutinin in complex with high affinity receptor analogs. Structure 2 719-731, 1994. 

From this equation it can be seen that for a given receptor density systems can spontaneously produce physiological response and that this response is facilitated by high G-protein concentration, high-affinity receptor/ G-protein coupling (low value of KG), and/or a natural tendency for the receptor to spontaneously form the active state. This latter property is described by the magnitude of L, a thermodynamic constant unique for every receptor. 

The use of radiolabelled Ca channel effectors has shown that L-type Ca " channels possess several specific high affinity receptors for these agents, most of which bind the drugs with dissociation constants in the nM range [41 4]. In addi-... 

Fc,RI High affinity receptor for IgE Fc,RII Low affinity receptor for IgE FcR Receptor for Fc region of antibody... 

The aforementioned results are consistent with the view that the rat brain PCP/"sigma opiate" high-affinity receptor is associated with the voltage-regulated, non inactivating K channels in the pre-synaptic terminals. Thus, we reasoned that the elucidation of the molecular composition of this PCP "receptor" might provide direct information about the subunit composition of these K channels. 

Type I reactions occur when the drug or its bound hapten incites an IgE antibody response. IgE binds to high-affinity receptors on mast cells and basophils. When the original antigen cross-links the cell-bound IgE, the effector cell releases enormous amounts of preformed mediators, producing the... 

Immunoglobulin receptors, such as the high affinity receptor for IgE, are present on mast cells and bloodbome basophils. These receptors play an important role in hypersensitivity and the initiation of acute inflammatory responses. 

Calvo, D, Gomez-Coronado, D, Lasuncion, MA, and Vega, MA, 1997. CLA-1 is an 85-kD plasma membrane glycoprotein that acts as a high-affinity receptor for both native (HDL, LDL, and VLDL) and modified (OxLDL and AcLDL) lipoproteins. Arterioscler Thromb Vase Biol 17, 2341-2349. 

IL-2 induces its characteristic biological activities by binding a specibc receptor on the surface of sensitive cells. The high-affinity receptor complex consists of three membrane-spanning polypeptide chains (a, P and y Table 9.2). 

Synaptic stimulation, ischemia or seizure activates phospholipase A2 and releases arachidonic and docosahexaenoic acids 578 Secretory phospholipases A2 are of relatively low molecular weight and have a high number of disulfide bridges, making them relatively more resistant to denaturation 579 There are high-affinity receptors that bind secretory phospholipase A2 579... 

Guo, Z., Liliom, K., Fischer, D. J. etal. Molecular cloning of a high-affinity receptor for the growth factor-like mediator lysophosphatidic acid from Xenopus oocytes. Proc. Natl Acad. Sci. U.S.A. 93 14367-14372,1996. 

Repp, R., Valerius, T., Sendler, A., Gramatzki, M., Iro, H., Kalden, J. R., Platzer, E. (1991). Neutrophils express the high affinity receptor for IgG (FcyRI, CD64) after in... 

Lippiello PM, Sears SB, Fernandes KG (1987) Kinetics and mechanism of L-[ H]nicotine binding to putative high affinity receptor sites in rat brain. Mol Pharmacol 31 392-400... 

Figure 5.3 Diastereoselective amplization of an alternating, meso arrangement of dithiols to create a high affinity receptor for NlCHj). ...

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