A High-Affinity Lipoxin Receptor

The lipoxins are produced by the sequential actions of multiple lipoxygenases on arachidonic acid and exert a variety of biological effects. In human neutrophils, the responses to lipoxin A4 include inhibition of chemotaxis and calcium mobilization, and they are likely to be mediated by a high-affinity membrane receptor coupled to a pertussis toxin-sensitive G protein (Gi or Go) (see chapter 4 and ref. 95). 

A complementary DNA encoding for what may be a lipoxin A4 receptor was identified in the laboratory of Charles N. Serhan.  

Nestler EJ, Greengard P. Protein Phosphorylation in the Nervous System. New York Wiley, 1984. 

O Brian CA, Ward NE, Weinstein IB, Bull AW, Marnett LJ. Activation of rat brain protein kinase C by lipid oxidation products. Biochem Biophys Res Commun 1988 155 1374-1380. 

Hansson A, Serhan CN, Haeggstrom J, Ingelman-Sundberg M, Samuelsson B. Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachi-donic acid. Biochem Biophys Res Commun 1986 134 1215-1222. 

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