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INDEX receptors, high-affinity

Systemically administered retinoids such as isotretinoin (1, Accutane ) have several disadvantages such as a relatively narrow therapeutic index and a variety of toxic effects including teratogenicity. Topically administered retinoids may avoid some of those drawbacks. For instance, tazarotene (2, Tazorac ) is a topical receptor-selective retenoid that normalizes differentiation and proliferation of keratinocytes. Its major metabolite, tazarotenic acid (11), binds to retinoic acid receptors (RARs) with high affinity. [Pg.59]

See other pages where INDEX receptors, high-affinity is mentioned: [Pg.626]    [Pg.182]    [Pg.626]    [Pg.795]    [Pg.12]    [Pg.45]    [Pg.920]    [Pg.795]    [Pg.353]    [Pg.99]    [Pg.879]    [Pg.226]    [Pg.58]    [Pg.256]    [Pg.458]    [Pg.763]    [Pg.337]    [Pg.289]    [Pg.73]    [Pg.314]    [Pg.537]    [Pg.38]    [Pg.360]    [Pg.301]   
See also in sourсe #XX -- [ Pg.253 ]



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High-affinity

High-affinity receptors

Receptor INDEX

Receptor affinity

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