Herpes viral proteins

Herpes Viral Proteins Manipulating the Peptide Transporter TAP... 

Herpes Viral Proteins Blocking the Transporter Associated with Antigen Processing TAP -From Genes to Function and Structure... 

T. Derfuss and E. Meinl Herpes viral Proteins Regulating Apoptosis... 

Interferons (IFN) are glycoproteins that, among other products, are released from virus-infected cells. In neighboring cells, interferon stimulates the production of "antiviral proteins." These inhibit the synthesis of viral proteins by (preferential) destruction of viral DNA or by suppressing its translation. Interferons are not directed against a specific virus, but have a broad spectrum of antiviral action that is, however, species-specific. Thus, interferon for use in humans must be obtained from cells of human origin, such as leukocytes (IFN-a), fibroblasts (IFN-P), or lymphocytes (IFN-y). Interferons are also used to treat certain malignancies and autoimmune disorders (e.g., IFN-a for chronic hepatitis C and hairy cell leukemia IFN-p for severe herpes virus infections and multiple sclerosis). 

Herpes simplex virus type 1 (HSV-1) is a double-stranded DNA virus that has a genome size of 152 Kb, and it encodes at least 84 proteins. Binding and entry of HSV-1 into permissive cells is mediated by viral proteins binding to cellular... 

Honess RW, Roizman B (1974) Regulation of herpes virus macro-malecular synthesis Cascade regulation of three groups of viral proteins. J Virol 14 8-19. 

Subsequent steps in AAV replication depend completely on gene products of unrelated helper vimses, and therefore vims production is propagated only upon coinfection. Ad or herpes vims can serve as a helper vims, and upon infection their viral proteins regulate AAV replication from initiation of transcription to... 

Viruses (from the Latin virus referring to poison) are nonliving obligate intracellular parasites composed of protein and nucleic acid (DNA or RNA) that manipulate the host cell to produce and manufacture more viruses. Viral infection occurs by tire attachment of virus particles to specific cell receptors within the host cell. After fusion of the host cell plasma membrane with the virus outer envelope, the protein-based viral nucleocapsid (containing the viral DNA) is transported to the host cell nucleus, where components of the viral particle inhibit macromolecular synthesis by tire host cell. Herpes viral DNA and new viral nucleocapsid synthesis occurs within the host nucleus, with the acquisition of new viral envelopes via a budding process through the inner membrane of the host nucleus. The mature newly synthesized viral particles are subsequently... 

A further report has been made on phaglcin, a protein material from phage-infected Escherichia coli that has shown antiviral effects against vaccinia and herpes simplex infections of the eye.Apparently this protein is a poor antigen. Hydroxyurea is an inhibitor of DNA synthesis in a number of biologic systems, including those of vaccinia and herpes simplex viruses. Because viral protein synthesis... 

Most of the viruses that contain DNA (e.g., herpes) use this as a direct template for m-RNA production using host cell DNA-directed RNA-polymerase. However, the pox viruses have their own RNA polymerase. Finally, the so-called retroviruses like HIV use their RNA as a blueprint for the production of a complementary DNA strand with the help of an enzyme called reverse transcriptase - an RNA-dependent DNA polymerase. This nomenclature arises from the fact that these organisms operate in reverse of the normal cellular replicative process whereby DNA acts as a blueprint for RNA production. The DNA thus produced is incorporated into host cell DNA with the help of another viral enzyme - HIV integrase - and the cell ultimately produces new viral genomic RNA and viral proteins using its normal replication procedures. 

Other applications of this type of detection include Western blotting procedures for the identification and visualization of protein antigens (LI, L8, L9). One such recent assay for herpes simplex virus Type 2 showed that enhanced chemiluminescence is 500 times more sensitive than a colorimetric method (Dl). Antibodies to several of the HIV viral proteins have also been detected in chemiluminescent Western blots (SI6). 

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