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Herbal medicines drug interactions

Izzo, A. A. 8c Ernst, E. (2001). Interactions between herbal medicines and prescribed drugs a systematic review. Drugs, 61, 2163-75. [Pg.108]

Ioannides, C., Pharmacokinetic interactions between herbal remedies and medicinal drugs, Xenobiotica, 32, 451, 2002. [Pg.203]

Miller, L.G., Herbal medicinals Selected clinical considerations focusing on known or potential drug-herb interactions, Arch Intern Med, 158, 2200, 1998. [Pg.203]

As already discussed, the same cannot be said for natural products used as dietary supplements. In most cases, those drugs have not heen subjected to the programs of testing required for FDA approval. As a result, products may pose a hazard to human health. Those hazards usually fall into one of four categories (1) the product may prevent a person from receiving other forms of FDA-approved medication that may he more beneficial to them (2) it may interact with other herbal medicines, prescribed drugs, and over-the-counter medications, with harmful effects (3) it may have no effect at all on a person s health or well-being or (4) it may actually cause harm to a person s health. [Pg.47]

III.d.5. Drug Interactions with Herbal and Traditional Medicines... [Pg.153]

Detractors of herbal medicine use have legitimate concerns about dosage variability, possible toxicity and adulteration, herb-drug interactions, and above all, lack of FDA regulation. Far from being intrinsically harmless, many pharmacologically active plant alkaloids and other compounds are natural defensive poisons their very effectiveness may be an unanticipated consequence of their adaptive toxicity to grazing animals and... [Pg.786]

D Arcy PF. Adverse reactions and interactions with herbal medicines. Part 2. Drug interactions. Adverse Drug React Toxicol Rev 1993 12 147-162. [Pg.161]

Ernst E. Herbal medicine where is the evidence BMJ 2000 321 395-396. Fugh-Berman A. Herb-drug interactions. Lancet 2000 355 134—138. [Pg.43]

Izzo A A, Di Carlo G, Borrelli F, Ernst E. Cardiovascular pharmacotherapy and herbal medicines the risk of drug interaction. Int J Cardiol 2005 98(1) 1-14. [Pg.179]

However, the information derived from a detailed pharmacokinetic study will help to anticipate potential botanical product-drug interactions, to optimize the bioavailability, the quality, and hence the efficacy of herbal medicines, to support evidence for the synergistic nature of herbal medicines, and to better appreciate the safety and toxicity of the plant. Because pharmacokinetic studies with herbal medicines are often complicated by their chemical complexity and by the fact that the active compounds are often unknown, it could be one future issue to assess bioavailability by measuring surrogate parameters in plasma or tissue instead of directly assaying putative active compounds in the blood. In summary, to use HMPs in an evidence-based approach and to achieve the status rational phytomedicine, more experimental studies are needed to characterize the bioavailability and pharmacokinetics of botanical products. [Pg.235]

Williamson EM. Drug interactions between herbal and prescription medicines. Drug Safety 2003 26(15) 1075-1092. [Pg.283]

Dergal JM et al Potential interactions between herbal medicines and conventional drug therapies used by older adults attending a memory clinic. Drugs Aging 2002 19 879. [PMID 12428996]... [Pg.1282]

Continuing in the tradition of the acclaimed first edition. Pharmacodynamic Basis of Herbal Medicine, Second Edition examines in extensive detail the physiologic effects of complementary and alternative therapies, foods, supplements, vitamins, and traditional herbal remedies. This encyclopedic volume considers the site, mode, and mechanism of action to explain the desired and adverse effects and interactions of each herb, drug, and food. [Pg.701]

Interactions of antidepressants with herbal medicines have been reported (62). Herbal medicines are widely used for their psychotropic properties and patients sometimes take herbal formulations in addition to conventional psychotropic drugs, such as antidepressants. Ginseng has been reported to cause mania, tremor, and headache in combination with conventional MAO inhibitors. [Pg.83]

Herbal medicines are becoming more and more popular, and indeed some herbal products may be considered to benefit people with liver disease, e.g. Silybum marianum (milk thistle), Picrorhiza kurroa, Phyllanthus, etc. Herbal hepatotoxicity is increasingly being recognised, for example, with kava kava, black cohosh, and many traditional Chinese remedies. The range of liver injury includes minor transaminase elevations, acute and chronic hepatitis, steatosis, cholestasis, zonal or diffuse hepatic necrosis, veno-occlusive disease and acute liver failure. In addition to the potential for hepatotoxicity, herb-drug interactions may affect the safety and efficacy of concurrent medical therapy [15]. [Pg.142]

In 2009, in the UK, drugs are increasingly available over the counter and on-line without prescription. Furthermore, there is widespread use of numerous herbal medicines from relatively under-regulated suppliers and the constituents of such products are often not known, This clinical reality of the widespread use of potent medicines - be they allopathic or traditional - showed us the need for a practical hands-on guide that aims to be a compact, succinct and accessible source of information for practitioners, prescribers and the public about adverse drug interactions,... [Pg.803]


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