HepG2 hepatocellular carcinoma cells

The amino acid sequence of the human erythrocyte glucose transporter was deduced from the nucleotide sequence of a cDNA clone in 1985 [106]. Polyclonal antibodies raised against the protein were used to screen a Xgtl I cDNA library prepared from the human hepatocellular carcinoma cell line HepG2. (Like many other transformed... 

Hou et also demonstrated that dihydroartemisinin (39), artemether (40) and artesunate (41) (Fig. 4) were able to inhibit the growth of four human hepatocellular carcinoma cells (HepG2, p53 wild-type Hep3B, p53 null Huh-7, p53 mutant and BEL-7404, p53 mutant). The IC50 values averaged 10.8 /tmol/L (1), 10.6 /tmol/L (39), 21.0 /tmol/L (41), and... 

HEPES Ar-(2-hydroxyethyl)piperazine-A,-(2-ethanesulfonic acid) HepG2 human hepatocellular carcinoma cells HFE a gene for hemochromatosis... 

Buchner RR, Hugh TE, Ember JA, Morgan EL (1995) Expression of functional receptors for human C5a anaphylatoxin (CD88) on the human hepatocellular carcinoma cell line HepG2. Stimulation of acute-phase protein-specific mRNA and protein synthesis by human C5a anaphylatoxin. J Immunol 155 308-315. 

Bae, M. H., Lee, M. J., et al. (1998). Insulin-like growth factor II (IGF-II) secreted from HepG2 human hepatocellular carcinoma cells shows angiogenic activity. Cancer Lett 128(1) 41-6. 

The compound saikosaponin d induced apoptosis in human hepatocellular carcinoma cells (HepG2) through the activation of caspases 3 and 7, resulting in poly(ADP-ribose)-poly-merase (PARP) cleavage. DNA fragmentation was clearly noted at more than 6 hours after exposure to saikosaponin d (Chiang et al. 2003). 

HepG2 cells human hepatocellular carcinoma cell line... 

Harmine Nuclear fragmentation and chromosomal condensation, A m dissipation, caspase-3 and caspase-9 activation, down-regulation of Bcl-2, Mcl-l and Bcl-xl, without change in Bax. Human hepatocellular carcinoma cell line HepG2 Harmine is a major component isolated from Peganumharmala L. (Zygophyllaceae) seed extract. Other effect reported antinociceptive and DNA topoisomerase inhibitor. [133]... 

Wang, W., Yao, J., Zhou J. P. et al. 2008a. Urocanic acid-modified chitosan-mediated p53 gene delivery inducing apoptosis of human hepatocellular carcinoma cell line HepG2 is involved in its antitumor effect in vitro and in vivo. Biochem. Biophys. Res. Commun. 377 567-572. 

Nanoscaled particles with a disk-shaped lipid bilayer stabilized by an apolipo-protein scaffold (curcumin nanodisks, NDs, with <50 nm size) have been used for encapsulating curcumin. NDs self-assemble in solution upon presentation of the scaffold protein to a phospholipid vesicle substrate to which an appropriate hydro-phobic bioactive agent has been introduced. The incorporation of curcumin into NDs enhanced growth inhibition of human hepatocellular carcinoma cells (HepG2) and induced apoptosis in mantle cell lymphoma (Jeko cells) [115,116]. Natthakittaet al. reported the development of mucoadhesive curcumin nanospheres. Ethyl cellulose... 

Cell lines established from human liver cancer cells can be derived from primary hepatocellular carcinoma or hepatoblastoma cells [10]. For example, the well known HepG2 fine was derived from hepatoblastoma cells. Such cells can be employed effectively if the function of normal liver cells has been highly preserved. In practice, however, such cells contain a high proportion of abnormal genetic component, which inhibits their ability to express normal protein synthesis and enzyme activity. Potential problems, such as the loss of liver specific functions and the possibifity of metastasis, which could arise from the use of hepatoma cells have not yet been satisfactorily discussed [13]. 

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