Receptor hepatocyte growth hormone

Brameld, J. M., Gilmour, R. S., and Buttery, P. J., Glucose and amino acids interact with hormones to control expression of insulin-like growth factor-I and growth hormone receptor mRNA in cultured pig hepatocytes, /. Nutr., 129, 1298,1999. 

Sugiyama and Kato [63] described a model for the receptor-mediated endocytosis of the polypeptide hormones epidermal growth factor (EGF) and hepatocyte growth factor (HGF) in isolated perfused rat liver and in isolated rat hepatocytes, to estimate the efficiency of dmg targeting using these polypeptide hormones as potential drng carriers. 

IGF-1 Insulin-like growth factor-1, also called somatomedin C a 70-amino acid peptide that shares structural homology with proinsulin. IGF-1 is synthesized and released by the hver in response to growth hormone binding to receptors on the hepatocyte. 

Somatotropin Growth hormone a 191-amino acid polypeptide hormone that is synthesized and secreted from the somatotroph cells of the anterior pituitary. It acts primarily on hepatocytes, although muscle and adipose cells also have receptors for growth hormone. 

Toilet, P., B. Enberg, and A. Mode (1990). Growth hormone (GH) regulation of cytochrome P-45011C12, insulin-like growth factor-1 (lGF-1), and GH receptor messenger RNA expression in primary rat hepatocytes A hormonal interplay with insulin, IGF-1, and thyroid hormone. Mol. Endocrinol. 4, 1934-1942. 

Donner, D. (1983). Covalent Coupling of Human Growth Hormone to Its Receptor on Rat Hepatocytes, J. Biol. Chem. 258 2736-2743. 

CYP cytochrome P450 GH growth hormone GHR GH receptor HNF hepatocyte nuclear factor 3MC 3-methylcholanthrene MSG monosodium glutamate SOCS suppressor of cytokine signaling protein STAT signal transducer and activator of transcription. 

The hepatocyte is the cell that carries out the many functions of the hver. Almost all pathways of metabohsm are represented in the hepatocyte and these pathways are controlled through the actions of hormones that bind to receptors located on the plasma membrane of their cells. Although normally quiescent cells with low turnover and a long life span, hepatocytes can be stimulated to grow if damage occurs to other cells in the liver. The hver mass has a relatively constant relationship to the total body mass of adult individuals. Deviation from the normal or optimal ratio (caused, for example, by a partial hepatectomy or significant hepatic cell death or injury) is rapidly corrected by hepatic growth caused by a proportional increase in hepatocyte replication. 

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