Hepatic arteriosclerosis

Pregnancy (ergotamine s powerful uterine stimulant actions may cause fetal harm) hypersensitivity to ergot alkaloids peripheral vascular disease (eg, thromboangiitis obliterans, leutic arteritis, severe arteriosclerosis, thrombophlebitis, Raynaud s disease) hepatic or renal impairment severe pruritus coronary artery disease hypertension sepsis. The use of potent CYP3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) with dihydroergotamine is contraindicated. 

Contraindications Coronary artery disease, hypertension, impaired hepatic or renal function, malnutrition, peripheral vascular diseases (such as thromboangiitis obliterans, syphilitic arteritis, severe arteriosclerosis, thrombophlebitis, and Raynaud s disease), sepsis, severe pruritus... 

Of 34 Japanese patients with diabetes and chronic hepatitis, 18 were given glycyrrhizin 240-525 mg for over 1 year (447). This resulted in a significant lowering of total testosterone concentrations and increased arteriosclerotic plaque formation. The authors suggested that glycyrrhizin treatment was an independent risk factor for arteriosclerosis. The testosterone lowering effect of liquorice has been confirmed in another trial (448). 

More serious conditions for which people take herbal drugs include depression, irregular heartbeat and other heart problems, arthritis, arteriosclerosis (hardening of the arteries), asthma, high blood pressure, various cancers, diabetes, epilepsy, gallstones, sexually transmitted diseases, hepatitis, jaundice, malaria, measles, obesity, tetanus, tuberculosis, and ulcers. 

R6. Reardon, M. F.,. Sakai, H., and Steiner, G., Roles of lipoprotein lipase and hepatic triglyceride lipase in the catabolism in vivo of triglyceride-rich lipoproteins. Arteriosclerosis 2, 396-402 (1982). 

Arteriosclerosis affects the extrahepatic liver arteries with the same frequency as the mesenteric arteries, but less frequently than the splenic artery. The intrahepatic branches of the hepatic artery are usually only involved in pronounced arterial hypertension. In these patients, thickening of the media can be found in the small arteries of the portal fields. 

Because it appears that one common mechanism of the cerebral, cardiovascular, and hepatic effects may be an acceleration of the arteriosclerotic process (see Section 2.4), individuals at risk for arteriosclerosis or those with early arteriosclerosis would probably be at increased risk for health effects following exposure to carbon disulfide (NIOSH 1978). The mechanism for carbon disulfide acceleration of arteriosclerotic plaque formation involves direct injury to the vessel endothelium and changes in lipid metabolism. 

Trihexyphenidyl is contraindicated in patients with narrow-angle glancoma becanse drug-induced cycloplegia and mydriasis may increase intraocnlar pressure in patients with cardiac disorders, arteriosclerosis, renal disorders, hepatic disorders, hypertension, obstructive G1 or genitourinary tract disease, or snspected prostatic hypertrophy becanse the drug may exacerbate these conditions. 

The dose of fluoroquinolones should be lowered in patients with hepatic (liver) or renal (kidney) problems. Carefully monitor the serum level of fluoroquinolones for patients who have CNS disorders such as cerebral arteriosclerosis (hardening of the arteries in the brain), epilepsy (seizures), or alcoholism because they are at risk for CNS toxicity. 

Documented effects Cultivated forms of this species are used as a food with medicinal value to treat asthenia, constipation, and hepatitis and are used as a diuretic and prophylaxis to prevent arteriosclerosis and anemia (Karimov and Shomakhmudov 1993). 

Traditional use Fruits are widely used as a tonic, choleretic, and as a remedy for scurvy. An infusion of the fruits with honey is used to treat upper respiratory colds and coughs. A decoction of the roots is drunk to treat diarrhea. A decoction of the leaves is taken to treat dysentery and as a diuretic (Khodzhimatov 1989). The hips from this and related species are used to prevent scurvy and avitaminosis, to treat arteriosclerosis, cholecystitis, hepatitis, and gastrointestinal diseases, particularly with reduced bile production (Altimishev 1991). Oil of rose is used externally to treat cracked and injured nipples of breast feeding women, bedsores, trophic ulcers of the shins, and dermatosis (Muravyova 1978). The fruits are used to treat lung tuberculosis, diphtheria, scarlet fever, flu, and sore throat (Zakordonets 1953). 

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