Renal disorder

Kir 1.1. Bartter Syndrome. Several mutations in the core region as well as in the N and C terminus of Kir 1.1 are found in patients with hyperprostaglandin E syndrome (HPS renal disorder resulting from impairment of tubular reabsorption), an antenatal form of Bartter syndrome. Some of these mutations result in the loss of function of Kiri. 1 channels causing impaired renal K+ secretion and NaCl reabsorption. 

Ochratoxin A (OTA) is a my cotoxin produced by some species of Penicillium and Aspergillus. It is nephrotoxic to all animal species tested and the causal agent of mycotoxic porcine nephropathy (Krogh, 1978). It was previously associated with the human renal disorder, Balcan endemic nephropathy (BEN), and tumours of the urinary tract (Pfohl-Leszkowicz et al., 2002). Recently, another endemic kidney disease (Tunisian chronic interstitial nephropathy, CIN) was linked to OTA-contaminated food (Creppy, 1999 Wafa et al.,... 

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