Hemoglobins distribution

Flock EV, Bennett PH, Savage PJ, Webner CJ, Howard BV, Rushforth NB, et al. Bimodality of glycosylated hemoglobin distribution in Pima Indians relationship to fasting hyperglycemia. Diabetes 1979 28 984-9. 

EIDOS dassilication Extrinsic moiety Benzocaine Intrinsic moiety Hemoglobin Distribution Erythrocytes Outcome Oxidation of iron in hemoglobin... 

Hematological Methods. Hematological analyses can Include the determination of the total hemoglobin concentration (In g%), the packed cell volume (PCV In %), the red blood cell count (In 10 /mm ) and reticulocytes count (In %), calculation of the red cell Indices, examination of a blood film, tests to demonstrate the presence of Inclusion bodies and of sickle cells, tests to evaluate the distribution of fetal hemoglobin (Hb-F) Inside the red cells, the red cell osmotic fragility, the concentration of serum Iron (SI), total Iron binding capacity (TIBC), and the survival time of the red cells. Details of all... 

F, female M, male MCH, mean corpuscular hemoglobin MCHC, mean corpuscular hemoglobin concentration MCV, mean corpuscular volume RBC, red blood cell RDW, red blood cell distribution TIBC, total iron-binding capacity. 

Fig. 6. Terminal capping and lateral bulging of globular domains in the //-solenoid of the hemoglobin protease from E. coli (Otto et al., 2005). The //-solenoid domains are shown in blue and the remaining regions in dark yellow. (A) Ribbon diagram of the 3D structure and (B) linear map of the domain distribution within the amino acid sequence.

After injection into mice, mercuric chloride has been found to be distributed equally between erythrocytes and plasma in blood for up to 1 day after the administration [12, 13]. There is, however, a gradual increase in red blood cell/plasma ratio. In the erythrocytes, mercury is probably bound to sulphydryl groups on the hemoglobin molecule [14], though the binding is readily reversible [15]. There is possibly also a binding to glutathione [16]. 

Hemoglobin is directly measured and is an independent and continuous variable However, and probably because at any one time a number of forms and conformations (oxyhemoglobin, deoxyhemoglobin, methemoglobin, etc.) of hemoglobin are actually present the distribution seen is not typically a normal one, but rather may be a multimodal one. Here a nonparametric technique such as the Wilcoxon or multiple rank-sum is called for. 

This theory clearly predicts that the shape of the polymer length distribution curve determines the shape of the time course of depolymerization. For example Kristofferson et al. (1980) were able to show that apparent first-order depolymerization kinetics arise from length distributions which are nearly exponential. It should also be noted that the above theory helps one to gain a better feeling for the time course of cytoskeleton or mitotic apparatus disassembly upon cooling cells to temperatures which destabilize microtubules and effect unidirectional depolymerization. Likewise, the linear depolymerization kinetic model could be applied to the disassembly of bacterial flagella, muscle and nonmuscle F-actin, tobacco mosaic virus, hemoglobin S fibers, and other linear polymers to elucidate important rate parameters and to test the sufficiency of the end-wise depolymerization assumption in such cases. 

Awasthi VD, Garcia D, Klipper R, et al. Neutral and anionic liposome-encapsulated hemoglobin effect of postinserted poly(ethylene glycol)-distearoylphospha-tidylethanolamine on distribution and circulation kinetics. J Pharmacol Exp Ther 2004 309 241. 

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