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Microtubule destabilization

Cassimeris, L. The oncoprotein 18/stathmin family of microtubule destabilizers. Curr. Opin. Cell Biol. 14 18-24, 2002. [Pg.136]

Podophyllotoxin (38) Podophyllum peltatum L.), colchicine (9) Colchicum autumnale L.), vinblastine (4), and vincristine (5) Catharan-thus roseus (L.) G. Don] are standard microtubule-destabilizing agents used in cancer research. Paclitaxel (21), from Taxus brevifolia Nutt., acts as a promoter of stabilization of microtubules and causes mitotic arrest in an unusual fashion. ... [Pg.31]

Ogawa, T., Nitta, R., Okada, Y., and Hirokawa, N. (2004). A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops. CeU, 116, 591-602. [Pg.296]

Shirasu-Hiza, M., Coughlin, P., and Mitchison, T. (2003). Identification of XMAP215 as a microtubule-destabilizing factor in Xenopus egg extract by biochemical purification. J. Cell Biol. 161, 349-358. [Pg.297]

We have found that nearly all of the compounds that stabilize MTs also stabilize the 2-D crystals. Compounds that have been used include paclitaxel, epothilone-A and B, discodermolide and eleutherobin. Laulimalide, however, disrupts the sheets and causes them to reform into MTs. Microtubule destabilizing compounds have also been found to disrupt the crystals. [Pg.153]

Microtubule-Destabilizing Agents Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin... [Pg.195]

Molecular Modeling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents... [Pg.215]

See other pages where Microtubule destabilization is mentioned: [Pg.415]    [Pg.172]    [Pg.177]    [Pg.299]    [Pg.300]    [Pg.365]    [Pg.257]    [Pg.279]    [Pg.292]    [Pg.298]    [Pg.323]    [Pg.326]    [Pg.10]    [Pg.89]    [Pg.132]    [Pg.141]    [Pg.197]    [Pg.199]    [Pg.201]    [Pg.203]    [Pg.205]    [Pg.207]    [Pg.209]    [Pg.211]    [Pg.213]    [Pg.215]    [Pg.216]    [Pg.216]    [Pg.216]    [Pg.217]    [Pg.233]    [Pg.236]    [Pg.237]   
See also in sourсe #XX -- [ Pg.365 ]



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Destabilization

Destabilized

Destabilizers

Destabilizing

Microtubules

Microtubules destabilizers

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