Total hemoglobin response

No adverse hematological changes were observed in rats that were exposed to 24.4 or 174 mg/m of octaBDE dust for 8 hours/day for 14 consecutive days (IRDC 1978). Evaluation of hemoglobin, hematocrit, total erythrocyte count, and total and differential leukocyte counts showed no remarkable responses except for an elevation in leukocyte numbers. The observed increase in leukocyte counts was considered to be an unusual response by tlic investigators, although it was within the normal range for control rats in their laboratory. 

With the relationship between oxyhemoglobin concentration and erythropoietin production selected to provide good agreement of erythropoietin concentration changes and experimental data, the constants in Equation 2 (hemoglobin production) were modified to produce a better total hemoglobin response. The conditions were that (1) normal plasma... 

From the results of two other studies, in Bangladesh and Indonesia, that carefully monitored the number of iron tablets consumed, it appears that the size of the hemoglobin response to iron appears to depend on the total amount of iron consumed. In these studies, most of the hemoglobin response was produced by the first 20-50 tablets consumed. But more research is needed before recommendations can be made about consuming a fixed number of tablets over a defined period of time while permitting flexibility about the consumption interval (i.e., daily, two or three times per week, weekly, etc.). 

Total circulating red blood cell volume was calculated from experimentally determined values for mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV) (2) and the model predictions of total circulating hemoglobin. In response to stimulus, MCH is assumed to remain constant while MCV changes from the control value to a steady-state value (predetermined from the data) in a linear manner during the first 5 days of stimulus. 

The predictions for total hemoglobin and hemoglobin concentration from the modified model in response to continuous stimulation at 510, 440, and 360 mm Hg total pressure are shown in Figures 4, 5, and 6, respectively. The parameter values used in the simulation are shown in Table I. Although predictions are used to appraise the models validity, it should be remembered that the purpose of the model is not to produce an optimal fit between experimental data and model output but to help understand the behavior and interaction of the components and subsystems. 

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