Hematopoietic neoplasms leukemias

The hematopoietic neoplasms are a diverse group of malignancies tliat traditionally have been diagnosed by use of a variety of ancillary techniques. Important advances over the last few decades have elucidated the biological bases for the development of these diseases. The hematopoietic malignancies include the lymphomas, leukemias, and plasma cell dyscrasias. These diseases represent neoplastic proliferations of the hematopoietic system and are characteri2ed by monoclonality, clonal progression, clonal dominance, and suppression of normal clones. 

Two other hematopoietic neoplasms that may present in the mediastinum are granulocytic sarcoma (extramedullary myelogenous leukemia Fig. 11.28) ... 

Virtually any type of tumor, including soft tissue tumors and hematopoietic neoplasms such as lymphoma and leukemia, can involve the ovaries, either primarily or as metastases from a distant site. Many of these have specific immunohistochemical features, as detailed elsewhere in this book, which can be used to assist in their diagnosis. 

Occupational exposure to tetrachloroethylene and other solvents did not generally result in increased risk of hematopoietic neoplasms. Although there was one report of familial chronic l5miphocytic leukemia in five of seven members of a family who had worked for years in the dry cleaning industry (Blattner et al. 1976), it appears that an inherited defect was ihe cause of this family s susceptibility to leukemia. In addition, there was a study on occupational exposure of parents whose children had acute nonl miphocytic leukemia. Paternal (but not maternal) exposure to agents categorized as "solvents" was reported to pose a significant risk for development of childhood leukemia (Buckley et al. 1989). However, the risk was... 

Harshbarger, J.C., and C.J. Dawe Hematopoietic Neoplasms in Invertebrate and Poikilothermic Vertebrate Animals. In Unifying Concepts of Leukemia, Bibl. haemat. No. 39, (Dutcher, R.M., and L. Chieco-Bianchi, eds.), p. 1. Basel Karger. 1973. 

Secondary paraproteinemias may be seen in association with hematopoietic cancers (e.g., lymphomas and leukemias), other neoplasms (e.g., colon carcinoma), long-standing chronic urinary or biliary tract infection, rheumatoid factor related to IgM monoclonal protein, and amyloidosis. 

Statistically non-significant SMRs were obtained for mortalities from the following hematologic-related cancers combined neoplasms of the lymphatic and hematopoietic tissues, lymphosarcoma and reticulosarcoma, Hodgkins disease, leukemia and aleukemia, other lymphatic neoplasms. 

---