Tolerance, patient

After several minutes the peel can induce an anesthetic effect whereby increasing patient tolerance... 

Cardiac function (i.e., can the patient tolerate negative inotropic medications)... 

Sodium bicarbonate tablets are administered in increments of 325 and 650 mg tablets. A 650 mg tablet of sodium bicarbonate contains 7.7 mEq (7.7 mmol) each of sodium and bicarbonate. Sodium retention associated with sodium bicarbonate can cause volume overload, which can exacerbate hypertension and chronic heart failure. Patient tolerability of sodium bicarbonate is low because of carbon dioxide production in the GI tract that occurs during dissolution. 

Use of the first-generation somatostatin analog octreotide is limited by its extremely short duration of action and requirement for subcutaneous administration at least three times a day. If a patient s GH level returns to baseline before the end of an 8-hour dosing interval, the frequency of octreotide administration can be increased to every 4 to 6 hours. Most patients require octreotide in doses of 100 to 200 meg three times daily.19,20 To improve patient tolerance to gastrointestinal (GI) adverse effects, start octreotide at 50 meg every 8 hours.20 Assess IGF-I serum concentrations every 2 weeks after initiating therapy to further titrate dose in increments of 50 meg per dose. 

Since POAG is a chronic, often asymptomatic condition, the decision of when and how to treat patients is difficult since the treatment modalities are often expensive and have potential adverse effects or complications. The clinician should evaluate the potential effectiveness, toxicity, and the likelihood of patient adherence for each therapeutic modality. The ideal therapeutic regimen should have maximal effectiveness and patient tolerance to achieve the desired therapeutic response. The American Academy of Ophthalmology (AAO) publishes Preferred Practice Patterns for POAG and POAG Suspect.2... 

Response to antifungal therapy in invasive candidiasis is often more rapid than for endemic fungal infections. Resolution of fever and sterilization of blood cultures are indications of response to antifungal therapy. Toxicity associated with antifungal therapy is similar in these patients as described earlier with the caveat that some toxicities maybe more pronounced in crit-ically-ill patients with invasive candidiasis. Nephrotoxicity and electrolyte disturbances, with amphotericin B in particular, are problematic and may not be avoidable even with lipid amphotericin B formulations. Fluconazole and echinocandins are generally safer options, and are generally well tolerated. Decisions to use one class of agents over the other is principally driven by concerns of non-albicans species, patient tolerability, or history of prior fluconazole exposure (risk factor for non-albicans species.). 

Alternative first-line regimen Addition of IP therapy. Patient selection is critical Must have optimally debulked disease (less than or equal to 2 cm), no significant comorbidities, younger patients tolerate better. 

The association between low TPMT activity and excessive hematological toxicity has been recognized [31, 35, 37]. Molecular analysis of the TPMT genotype is able to identify patients at risk for acute toxicity from thiopurines. A recent study involving 180 children identified that the TPMT genotype plays an important role in a patients tolerance to 6-MP therapy [51]. Two of the patients, who were TPMT-de-... 

Not only was Phil a good statistician, but he was good-natured. He patiently tolerated my endless tabulations, graph-making and curve-fitting attempts. He also... 

Anxiety. Like psychosis, choosing a medication to treat anxiety in demented patients depends in large part on whether the anxiety is acute or longstanding. Acute severe anxiety requires rapid relief. For this, we recommend a benzodiazepine. Our first choice is lorazepam (Ativan) that is given as needed at 0.25-0.5 mg per dose. We prefer lorazepam because elderly patients tolerate it well (i.e., they metabolize it easily), and it is available in both oral and injectable forms. Oxazepam (Serax) is another benzodiazepine that older patients metabolize easily, but it is only available in oral form. When using benzodiazepines, be careful that your patients do not become overly sedated or delirious. 

Patients tolerant to or physically dependent on op/o/c/s. Nalmefene may cause acute withdrawal symptoms in individuals who have some degree of tolerance to and dependence on opioids. Closely observe these patients for symptoms of withdrawal. Administer subsequent doses with intervals of at least 2 to 5 minutes between doses to allow the full effect of each incremental dose of nalmefene to be reached. Reversal of postoperative opioid depression Use 100 mcg/mL dosage strength (blue label) refer to the following table for initial doses. The goal of treatment with nalmefene in the postoperative setting is to achieve reversal of excessive opioid effects without inducing a complete reversal and acute pain. This is best accomplished with an initial dose of 0.25 mcg/kg followed by 0.25 mcg/kg... 

Control can be achieved in most patients with 200 to 300 mg given every 8 hours. If satisfactory response is not achieved at 300 mg every 8 hours, and the patient tolerates mexiletine well, try 400 mg every 8 hours. The severity of CNS side effects increases with total daily dose do not exceed 1200 mg/day. 

HP Only give the HP strength (10 mg/mL) to patients tolerant of other... 

Early phase treatment - Increase dosage to 60 mg/day or more at a fairly rapid pace consistent with patient tolerance. It may be necessary to increase dosage up to 90 mg/day to obtain sufficient MAO inhibition. Many patients do not show a clinical response until treatment at 60 mg has been continued for at least 4 weeks. 

Give patients in an off state a 0.2 mL (2 mg) test dose where blood pressure can be closely monitored by medical personnel. Check supine and standing blood pressure predose and at 20, 40, and 60 minutes postdose. Do not consider patients who develop clinically significant orthostatic hypotension as candidates for treatment. If the patient tolerates the 0.2 mL (2 mg) dose and responds, use the starting dose of 0.2 mL (2 mg) on an as-needed basis to treat existing off episodes. If needed, the dose can be increased in 0.1 mL (1 mg) increments every few days on an outpatient basis. 

IV For doses less than or equal to 2400 mg/day, infuse at a rate of approximately 2 hours/amp. For doses greater than 2400 mg/day, adjust infusion rate and diluent according to patient tolerability. 

Because patient tolerance varies greatly, a test dose may be preferred 1 mg in 20 ml of 5% Dextrose delivered IV over 20 to 30 minutes. Record patient s temperature, pulse, respiration, and blood pressure every 30 minutes for 2 to 4 hours. 

Give nitrofurantoin with food to improve drug absorption and, in some patients, tolerance. 

Follow-up Follow-up with 1.5 years Less than 50 g/ No Normal serology Normal histology Most CD patients tolerate... 

In the meantime, there is continued interest in exploiting the use of induction ChT along with concurrent chemoradiation to maximize the opportunity to control occult micrometastases. There are potential downsides to this approach, as the induction ChT could reduce patient tolerance for the subsequent concurrent component. The induction ChT can also potentially stimulate accelerated tumor cell repopulation so that an additional burden of avidly dividing tumor is placed upon the subsequent concurrent chemoradiation. 

Which route of administration is optimum Choosing the optimum dmg administration route takes into account the specific circumstances of each individual case. For example, can the patient tolerate oral medications, or is intravenous administration required Does the patient have venous access For how long can it be maintained Is intramuscular administration a possibility In many clinical situations, the available formulation determines the route of administration. Antibiotics are a prime example of this phenomenon ceftriaxone, for example, is available only for parenteral administration while amoxicillin is administered orally. 

Pickford EJ et al. Infants and atropine A dangerous mixture. J Paediatr Child Health 1991 27 55-56. Ruckenstein MJ and Harrison RV. Motion sickness Helping patients tolerate the ups and downs. Postgrad Med 1991 89 139-144. 

Benzodiazepines are useful as orally administered premedications. They are also used intravenously in doses that produce conscious sedation rather than hypnosis. Sedated patients tolerate unpleasant procedures (e.g., wound repair, bronchoscopy, angiography) while maintaining cardiorespiratory function and the ability to respond to tactile stimulation or verbal commands. 

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