Lipids neutral heart

Table IV,. Fatty Acid Composition of Neutral Heart Lipids ...

Poulin and Theil have developed a mechanistic model for estimating the Vd based on physiologically based pharmacokinetics (PBPK). For this method, the tissue plasma partition coefficient for each organ of the body is calculated by consideration of the volume fraction of neutral and phospholipids and water found in the tissues of a particular organ. For example, the volume fraction of neutral lipids in human adipose tissue is 0.79 whereas the volume fraction of neutral lipids in cardiac tissue is 0.0115. By contrast the volume fraction of water in adipose and heart are 0.18 and 0.76 respectively. Combined with the P, these volume fractions are used to estimate the distribution of a drag molecule into each tissue. Summation of the product of tissue volume and tissue/plasma partition coefficient produces the estimate of Vd. ... 

Murphy EJ, Rosenberger TA, Patrick CB, Rapoport SI. Intravenously injected [l- C]arachidonic acid targets phospholipids and [ 1 - C pahn i lie acid targets neutral lipids in heart of awake rats. Lipids 2000 35(8) 891-898. 

Histologic analysis of hematoxylin and eosin stained sections of liver and heart from male PPARa -/- mice following a single injeetion of etomoxir revealed marked lipid accumulation in both organs with high fatty acid oxidative flux (Fig. 3 A). The sections were also stained with oil red O, a method for staining of neutral lipids (Fig. 3B). The livers of PPARa-/-male and female vehicle-treated eontrol mice contained patehy areas of small red droplets but not their heart, consistent with the existence of a mild... 

Dietary fatty acids will influence the cardiac phospholipid composition of the rat but to a lesser extent than the cardiac neutral lipids (Carroll, 1965). Dietary fatty acids may be incorporated as saturated and monounsaturated fatty acids, or they may be incorporated and converted to more polyunsaturated fatty acids (PUFA), i.e., linoleic acid to 20 4 n-6, 22 4 n-6, and 22 5 n-6 and linolenic acid to 20 5 r/-3, 22 5 n-3, and 22 6 n-3 (see Chapter 16). Dietary saturated and monounsaturated fatty acids are incorporated to a small extent into cardiac phospholipids (Carroll, 1965). On the other hand, dietary 18 2 n-6 and 18 3 n-3 cause a significant increase in the pentaenoic and hexaenoic acids which is greater in the heart than in any other organ of the rat (Rieckehoff et aL, 1949 Widmer and Holman, 1950). With this background it may be useful to discuss changes in the composition of the different cardiac phospholipids with diet. 

Christie (1987) discussed various functions of lipids as follow their involvement in disturbances of lipid metabolism associated with specific lipid disorders accumulation of various neutral, complex, and conjugated lipids in coronary artery and heart disease the role of lipids in nutrition, disease, and human welfare the importance of fats and oils as agricultural products and as major items in international trade the role of fats as a major dietary component and supplier of calories for humans in developed countries and the contribution that fats make to the taste and structure of foods. Ando and Saito (1987) contributed a review on TLC and HPTLC lipid analysis of normal and pathological tissues associated with specific lipidoses and gangliosidoses. 

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