Health and Welfare Canada

Pesticides Handlers Exposure Database (PHED) software, U.S. Environmental Protection Agency Health and Welfare Canada, National Agricultural Chemicals Association (U.S.) software originally issued February 1992 with subsequent upgrades. 

Environment Canada. 1992. Toxic chemicals in the Great Lakes and associated effects. Vol. II Effects. Ottowa, Canada Environment Canada, Health and Welfare Canada, Department of Fisheries and Oceans. March, 1992. 

The capsules contained a mean of 82 mg feverfew and thus the level of activity calculated as parthenolide can be estimated as 0.67%. Other studies quote 0.87% sesquiterpene lactones calculated as parthenolide [27] and 0.25-0.30% of active (antimicrobial) material [33]. Bohlmann s extraction of individual components from the dried plant yielded 116 mg sesquiterpene lactones/kg dried feverfew which amounts to less than 0.01 % [17]. Another extraction yielded 330 mg endoperoxides/kg and 56 mg canin/kg alone [19] which would amount to a level of sesquiterpene lactones of at least 0.04%. Thus, the level of sesquiterpene lactones appears to vary with different sources of the plant and this could have been due to a number of factors including the conditions in which feverfew was grown, the season in which it was picked and the way in which it was stored. Another important determinant of the parthenolide content of feverfew appears to be the geographical location. A recent survey of commercial preparations found that all the North American commercial products tested contained less that 0.1% parthenolide, wheras much higher values were obtained for British products. A minimum level of 0.2% parthenolide in commercial products has been proposed by the Health Protection Branch of Health and Welfare Canada [71]. 

Government of Canada. 1993. Canadian Environmental Protection Act. Priority Substances List Assessment report 3,3 -Diehlorobenzidine. Government of Canada, Health and Welfare Canada, Environment Canada. 

WHO (1994) has specified the daily amount of soil ingested as 20 mg/day. This is a median value from Health and Welfare Canada (the national Department of Health of the Government of Canada). It has not been specified whether this standard value is valid for adults or for children. 

Drugs Directorate Guidelines, Acceptable Methods, Health Protection Branch -Health and Welfare Canada, 1992,20-22. 

K Hughes, Health and Welfare Canada, Environmental Health Centre, 0802 BI, Tunney s Pasture, Ottawa, Ontario KIA OL2, Canada... 

Murugan Malaiyandi, EDITOR Health and Welfare Canada... 

Environmental Health Directorate, Health and Welfare Canada, Ottawa, Canada, after graduating from Madras University, received his B.Sc. (Hons) and M.Sc. in chemistry from the University of Mysore, India, and his Ph.D. from the University of Toronto, Toronto,... 

Canada. After 5 years of post-doctoral training, he joined the Canadian Department of Agriculture in 1965 and the Department of Health and Welfare Canada in 1976. 

This chapter is abstracted from a report presented to Health and Welfare Canada as part of contract number 887-1982/83. 

Health and Welfare Canada calculated a value of 0.02 mg/kg/day or 700 /zg/L by using 90 mg/kg/day as the minimum effect dose from the National Cancer Institute bioassay in the rat and applying a 5000-fold safety factor (40). 

In its chloroform guideline published in 1980, Health and Welfare Canada reported the following risk calculations based upon data from the Osbome-Mendel rat studies (the maximum dose for all models was 0.35 mg/L/day) ... 

Health and Welfare Canada Canadian Drinking Water Standards and Objectives (1968) Queens Printer Ottawa, 1969. 

Health and Welfare Canada Guidelines for Drinking Water Quality (1978) Canadian Government Publishing Centre Hull, 1979. 

Bureau of Chemical Safety, Health and Welfare Canada, Ottawa, Ontario, Canada College of Medicine, State University of New York, Health Science Center, Binghamton, NY... 

National Survey for Halocarbons in Drinking Water. Health and Welfare, Canada, 77-EHD-9... 

Ciba-Geigy Corporation, 1,34,71, 139,232,310 Harvard University, 16 Health and Welfare Canada, 341... 

The Testing of Chemicals for Carcinogenicity, Mutagenicity, and Teratogenicity published by the Ministry of National Health and Welfare (Canada)... 

Patten SB, Love EJ. Neuropsychiatric adverse drug reactions passive reports to Health and Welfare Canada s adverse drug reaction database (1965-present). Int J Psychiatry Med 1994 24(l) 45-62. 

Meranger JC, Davey ABC. 1989. Non-asbestos fibre content of selected consumer products. Ottawa, Ontario, Canada Environmental Health Directorate, Health and Welfare Canada, 347-353. 

Clinical Trial Review and Approval, Drugs Directorate, Policy Issues, Health and Welfare Canada, 1995. TPP (Therapeutic Products Program, Canada), http //www.hc-sc.gc.ca/hpb-dgps/ therapeut/htmleng/whatsnew.html. 

In Canada, new chemicals are controlled under the Canadian Environmental Protection Act (CEP A). The regulations promulgated under CEP A require producers of new chemicals to provide toxicological data and, when appropriate, SARs might be used as a substitute for experimental data (Environment Canada and Health and Welfare Canada, 1993). 

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