Pharmaceuticals hazard avoidance

Precaution Airborne dust may be an explosion hazard avoid dust formation take precautions against static discharge if dust formation occurs Hazardous Decomp. Prods. Heated to decomp., emits very toxic fumes of SOx, NOx, and Cr hydrogen chloride can be formed in fire Uses Colorant in cosmetics, lipsticks, mouthwashes, dentifrices, pharmaceutical topicals... 

Since full analyses are carried out, a lot of data are generated. Every parameter is reviewed for trends that signal product aging or outright decomposition of the active principle this can be as cosmetic in nature as discoloration or as potentially hazardous as buildup of toxic derivatives. If the drug substance is an ester, for example, hydrolysis, particularly if moisture penetrates the primary packaging material, will decompose the compound into its acid and alcohol components. From a pharmaceutical or medical viewpoint, even if there is no toxicity issue involved, this will result in a loss of bioavailability. Even this is to be avoided because subpotency introduces therapeutic uncertainty and can go as far as lethal undertreatment. 

Economic and safety considerations encourage minimal stockpiling of chemicals and avoiding transportation of hazardous substances. These increasing demands offer many opportunities for microwave chemistry in the development of environmentally benign methods for the preparation of intermediates, specialty chemicals and pharmaceuticals [6[. It appears likely that within the next few years, individual chemical reactors will be required for diverse tasks and will need to be easily relocated... 

Over the last decade, many aqueous dispersions of insoluble polymers have been developed and commercialized for the pharmaceutical industry1. These latices have stimulated interest for aqueous coating and granulation because they avoid problems associated with organic solutions such as air pollution, solvent toxicity and fire hazard. 

Toxicology LD50 (IP, mouse) 600 mg/kg, (oral, mammal) 700 mg/kg irritant to skin, eyes, mucous membranes lachrymator TSCA listed Precaution Combustible corrosive avoid contact with acid absorbs CO2 from air Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes Storage Store under nitrogen Uses Chemicai intermediate for dyes, pharmaceuticals, and polymers corrosion inhibitor for metalworking fluids base-... 

Precaution Avoid dust formation Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes of K2O Uses Mineral source, potassium carrier, nutrient, dietary supplement for pharmaceuticals (tablets), foods (dietetic foods), beverages, vitamin tablets sequestrant for foods paper and textile auxs. electroplating... 

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