Hair, fungal infections treatment

Over the last fifty years, as chemotherapeutics for the treatment of cancer, bacterial infections, and to prevent transplant rejections have improved, there has been a concomitant increase in the number of patients suffering from fungal infections. In the past, most fungal infections were superficial, affecting only the skin, hair, or nails. However, as medical science has progressed in other disease areas, many more patients are immunocompromised, which has resulted in a greater incidence of systemic fungal infections. 

Superficial fungal infections involve cutaneous surfaces, such as the skin, nails, and hair, and mucous membrane surfaces, such as the oropharynx and vagina. A growing number of topical and systemic agents are available for the treatment of these infections. Deep-... 

The polycyclic antibiotic, griseofulvin, is derived from Penicillium griseofulvum and is perhaps the most important agent in the systemic treatment of dermatophyte infections (Fig. 2). It is used orally for the treatment of superficial fungal infections of nails, hair, and skin, increasing the resistance of keratin to infection. Side effects of therapy are usually mild most common are nausea, diarrhoea and headaches (Swartz 1962). 

Terbinafine interferes with ergosterol biosynthesis, and thereby with the formation of the fungal cell membrane. It is absorbed from the gastrointestinal tract and undergoes extensive metabolism in the liver (tj 14 h). Terbinafine is used topically for dermatophyte infections of the skin and orally for infections of hair and nails where the site (e.g. hair), severity or extent of the infection render topical use inappropriate (see p. 315). Treatment (250 mg/d) may need to continue for several weeks. It may cause nausea, diarrhoea, dyspepsia, abdominal pain, headaches and cutaneous reactions. 

Staining Applications Acid fast bacilli cells nuclei smear sputum hairs Biological Applications Detecting bacteria treatment of cancers, cardiovascular disease, diabetes-associated pain, ° mechanical allodynia, metabolic syn-drome, protozoan infections in fish targeted drug delivery " as fungal inhibitors ... 

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