Transplant rejection prevention

These drugp possess anti-inflammatory activity and are used for inflammatory conditions, such as allergic conjunctivitis, keratitis, herpes zoster keratitis, and inflammation of the iris. Corticosteroids also may be used after injury to the cornea or after corneal transplants to prevent rejection. 

Zenapax Daclizumab Hoffman-La Roche Prevention of kidney transplant rejection... 

Corticosteroids also exert inhibitory effects on the overall immune process. These drugs impair the function of the leukocytes responsible for antibody production and destruction of foreign cells. As a result, corticosteroids are also used therapeutically in the prevention of organ transplant rejection. 

A 30-year-old male with a two-year history of chronic renal failure requiring dialysis consents to transplantation. A donor kidney becomes available. He is given cyclosporine to prevent transplant rejection just before surgery What is the most likely adverse effect of this drug ... 

Curran MP, Keating GM. (2005) Mycophenolate sodium delayed release Prevention of renal transplant rejection. Drugs 65 799-805. 

Both the prevention of transplant rejection and the treatment of autoimmune disorders call for a suppression of immune responses. However, immune suppression also entails weakened defenses against infectious pathogens and a long-term increase in the risk of neoplasms. 

The monoclonal antibodies daclizu-mab and basiliximab bind to the a-chain of the 11-2 receptor of T-lympho-cytes and thus prevent their activation, e.g., during transplant rejection. 

Over the last fifty years, as chemotherapeutics for the treatment of cancer, bacterial infections, and to prevent transplant rejections have improved, there has been a concomitant increase in the number of patients suffering from fungal infections. In the past, most fungal infections were superficial, affecting only the skin, hair, or nails. However, as medical science has progressed in other disease areas, many more patients are immunocompromised, which has resulted in a greater incidence of systemic fungal infections. 

Answer Cyclosporine is an immunosuppressant drug used to prevent transplant rejections. Though an oral formulation is available, it has low bioavailability (very httle reaches the systemic circulation as intact drug). Diltiazem will inhibit cytochrome P450 3A4 in the gut. CYP3A4 is the... 

Cyclosporine (Sandimmune) is a potent inhibitor of antibody- and cell-mediated immune responses and is the immunosuppressant of choice for the prevention of transplant rejection. It also has application in the treatment of autoimmune diseases. 

Unlabeled Uses Treatment of alopecia areata, aplastic anemia, atopic dermatitis, Behpet s disease, biliary cirrhosis, prevention of corneal transplant rejection... 

Mechanism of Action An immunologic agent that suppresses the immunologically mediated inflammatory response by inhibiting inosine monophosphate dehydrogenase, an enzyme that deprives lymphocytes of nucleotides necessary for DNA and RNA synthesis, thus inhibiting the proliferation of T and B lymphocytes. Therapeutic Effect Prevents transplant rejection. 

Prevention of organ transplant rejection PO Loading dose 6 mg. Maintenance 2 mg/day. 

Mechanism of Action An immunologic agent that inhibits T-lymphocyte activation by binding to intracellular proteins, forming a complex, and inhibiting phosphatase activity. Therapeutic Effect Suppresses the immunologically mediated inflammatory response prevents organ transplant rejection. 

The drugs like azathioprine and cyclosporine A are used chiefly to prevent transplant rejection and in the treatment of autoimmune diseases. They are used to prevent graft rejection after kidney, liver, lung, pancreas transplant or bone marrow transplantation. 

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