Polycyclic antibiotics

Macrocyclic glycopeptides. The first of these CSPs - based on the cavity of the antibiotic vancomycin bound to silica - was introduced by Armstrong [25]. Two more polycyclic antibiotics teicoplanin and ristocetin A, were also demonstrated later. These selectors are quite rugged and operate adequately in both normal-phase and reversed-phase chromatographic modes. However, only a limited number of such selectors is available, and their cost is rather high. 

Many of the polycyclic antibiotics are based on linear assemblies of three or more six-membered rings, such as the tetracycline and anthracycline antibiotics (examples are chlortetracycline and... 

Antifungal, Anthelmintic, and Antiprotozoal Drugs Fig. 2. Polycyclic antibiotics griseofulvin... 

The polycyclic antibiotic, griseofulvin, is derived from Penicillium griseofulvum and is perhaps the most important agent in the systemic treatment of dermatophyte infections (Fig. 2). It is used orally for the treatment of superficial fungal infections of nails, hair, and skin, increasing the resistance of keratin to infection. Side effects of therapy are usually mild most common are nausea, diarrhoea and headaches (Swartz 1962). 

Bister, B., Bischoff, D., Strdbele, M., Riedlinger, J., Reicke, A., Wolter, F., Bull, A.T., Ziihner, H., Fiedler, H.P., and Siissmuth, R.D. (2004) Abyssomidn C - A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway. Angew. Chem. Int. Ed., 43, 2574-2576. 

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